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Nature Reviews Drug Discovery
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57.62
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Papers 4546
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The success of targeted therapies in cancer treatment has been impeded by various mechanisms of resistance. Besides the acquisition of resistance-conferring genetic mutations, reversible mechanisms that lead to drug tolerance have emerged. Plasticity in tumour cells drives their transformation towards a phenotypic state that no longer depends on the drug-targeted pathway. These drug-refractory cells constitute a pool of slow-cycling cells that can either regain drug sensitivity upon treatment di...
Nearly ten compounds from zebrafish screens are in or about to enter the clinic, and zebrafish 'avatars' are gaining traction as a tool to guide treatment plans for patients with cancers and rare diseases. Nearly ten compounds from zebrafish screens are in or about to enter the clinic, and zebrafish 'avatars' are gaining traction as a tool to guide treatment plans for patients with cancers and rare diseases.
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