Respiratory Research
Papers 2708
1 page of 271 pages (2,708 results)
#1Bora Sul (Henry M. Jackson Foundation for the Advancement of Military Medicine)H-Index: 1
#2Lucia Flors (MU: University of Missouri)H-Index: 2
Last.Anders Wallqvist (DA: United States Department of the Army)H-Index: 1
view all 7 authors...
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease involving progressive degeneration of lung capacity. Current diagnosis of IPF heavily relies on visual evaluation of fibrotic features in high-resolution computed tomography (HRCT) images of the lungs. Although the characteristics of this disease have been studied at the molecular and cellular levels, little is known about the mechanical characteristics of IPF lungs inferred from HRCT images. To this end, we performed a pilot...
#1Frank AlbersH-Index: 5
#2Alberto Papi (University of Ferrara)H-Index: 66
Last.Namhee KwonH-Index: 7
view all 7 authors...
We assessed the efficacy of the licensed mepolizumab dose (100 mg subcutaneously [SC]) in patients with severe eosinophilic asthma according to body weight/body mass index (BMI). This was a post hoc individual patient-level meta-analysis of data from the Phase 3 studies MENSA (MEA115588/NCT01691521) and MUSCA (200862/NCT02281318). Patients aged ≥12 years with severe eosinophilic asthma and a history of exacerbations were randomised to 4-weekly placebo, mepolizumab 75 mg intravenously (IV) or 100...
#1Michael Kreuter (Heidelberg University)H-Index: 23
#2Jeffrey J. SwigrisH-Index: 46
Last.Juergen Behr (LMU: Ludwig Maximilian University of Munich)H-Index: 57
view all 26 authors...
Background Quality of life (QoL) is profoundly impaired in patients with idiopathic pulmonary fibrosis (IPF). However, data is limited regarding the course of QoL. We therefore analysed longitudinal data from the German INSIGHTS-IPF registry.
3 CitationsSource
#1Jin Jin (Juntendo University)
#2Shinsaku Togo (Juntendo University)H-Index: 16
Last.Kazuhisa Takahashi (Juntendo University)H-Index: 58
view all 18 authors...
Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1-induced IPF pathogenesis. However, unlike normal lung fibroblasts, the relationship between pirfenidone responses of TGF-β1-induced human fibrotic lung fibroblasts and lung fibrosis has not been elucidated. The effects of pirfenidone were evaluated in lung fibroblasts isolated from fibroti...
#1Peter Alter (University of Marburg)H-Index: 23
#2Henrik WatzH-Index: 28
Last.Rudolf A. Jörres (LMU: Ludwig Maximilian University of Munich)H-Index: 44
view all 11 authors...
Background COPD influences cardiac function and morphology. Changes of the electrical heart axes have been largely attributed to a supposed increased right heart load in the past, whereas a potential involvement of the left heart has not been sufficiently addressed. It is not known to which extent these alterations are due to changes in lung function parameters. We therefore quantified the relationship between airway obstruction, lung hyperinflation, several echo- and electrocardiographic parame...
#1Cassandra P. Nader (WIMR: Woolcock Institute of Medical Research)
#2Aylin Cidem (WIMR: Woolcock Institute of Medical Research)
Last.Alaina J. Ammit (UTS: University of Technology, Sydney)H-Index: 35
view all 4 authors...
Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impairment in COPD have been identified in LC. This suggests the two diseases are more linked than once thought. Emerging data in relation to a key phosphatase, protein phosphatase 2A (PP2A), and its regulatory role in inflammatory and tumour suppression in both disease settings suggests that i...
#1Nana Yang (WMU: Weifang Medical University)H-Index: 11
#2Hua TianH-Index: 10
Last.Shucun QinH-Index: 15
view all 12 authors...
Background Patients with acute lung injury (ALI) have increased levels of pro-inflammatory mediators, which impair endothelial progenitor cell (EPC) function. Increasing the number of EPC and alleviating EPC dysfunction induced by pro-inflammatory mediators play important roles in suppressing ALI development. Because the high density lipoprotein reverse-D-4F (Rev-D4F) improves EPC function, we hypothesized that it might repair lipopolysaccharide (LPS)-induced lung damage by improving EPC numbers...
#1Dave Singh (University of Manchester)H-Index: 50
#2Anthony D'Urzo (U of T: University of Toronto)H-Index: 22
Last.Edward KerwinH-Index: 20
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There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1 or the now-withdrawn GOLD stage 0) represents an early stage of COPD that may progress to more severe disease. This review summarises the disease burden of patients with mild COPD and discusses the evidence for treatment intervention in this subgroup. Overall, patients with mild COPD suffe...
1 CitationsSource
#1Dan Zhang (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 1
#2Xiuyu Lou (CDC: Centers for Disease Control and Prevention)H-Index: 4
Last.Xuejun Ma (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 16
view all 13 authors...
Background Viral respiratory infection (VRI) is a common contraindication to elective surgery. Asymptomatic shedding among pediatric surgery patients (PSPs) could potentially lead to progression of symptomatic diseases and cause outbreaks of respiratory diseases. The aim of this study is to investigate the incidence of infection among mild symptomatic PSP group and asymptomatic PSP group after surgical procedure.
#1Ghaleb Khirfan (Cleveland Clinic)H-Index: 3
#2Mostafa K. Ahmed (Assiut University)H-Index: 4
Last.Adriano R. Tonelli (Cleveland Clinic)H-Index: 18
view all 6 authors...
Introduction Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought to determine these gradients in group 1 PAH and assess their association with disease severity and survival.
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