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Arthritis Research & Therapy
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4.15
Papers
6462
Papers 6546
1 page of 655 pages (6,546 results)
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#1Keiko Yoshimoto (Keio: Keio University)H-Index: 17
#2Katsuya Suzuki (Keio: Keio University)H-Index: 17
Last. Tsutomu TakeuchiTsukasa (Keio: Keio University)H-Index: 63
view all 5 authors...
We reported that the production of BAFF (B cell-activating factor) and IL-6, both of which are involved in survival and differentiation of B cells, is dysregulated in monocytes of patients with primary Sjogren’s syndrome (pSS). In this study, we investigate the relationship between possible aberrations of pSS monocytes and clinical features of pSS patients and the contribution of monocytes to B cell activation, a mechanism involved in the pathogenesis of pSS. Expression of BAFF-receptor (BR3) on...
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#1Samaneh Maleknia (UT: University of Tehran)
#2Zahra Salehi (Tehran University of Medical Sciences)H-Index: 2
Last. Kaveh Kavousi (UT: University of Tehran)H-Index: 6
view all 5 authors...
A comprehensive intuition of the systemic lupus erythematosus (SLE), as a complex and multifactorial disease, is a biological challenge. Dealing with this challenge needs employing sophisticated bioinformatics algorithms to discover the unknown aspects. This study aimed to underscore key molecular characteristics of SLE pathogenesis, which may serve as effective targets for therapeutic intervention. In the present study, the human peripheral blood mononuclear cell (PBMC) microarray datasets (n =...
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#1Xia Jiang (KI: Karolinska Institutet)H-Index: 12
#2Lars Alfredsson (KI: Karolinska Institutet)H-Index: 88
Rheumatoid arthritis (RA) is a multifactorial chronic autoimmune disease, which involves a complex interplay of environmental triggers and genetic components in its etiology. It has been shown that genetics only explain about half of the liability to develop RA, leaving a large room for non-genetic factors. Indeed, several environmental exposures including smoking, drinking, obesity, and dietary patterns (and more) have been identified to be associated with RA risk, yet the observational nature ...
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#1Piero Ruscitti (University of L'Aquila)H-Index: 20
#2Onorina Berardicurti (University of L'Aquila)H-Index: 15
Last. Fabiola Atzeni (UNIME: University of Messina)H-Index: 48
view all 17 authors...
BACKGROUND Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown aetiology usually affecting young adults. Interestingly, recent evidence from the juvenile counterpart of AOSD suggested the emergent high fatality rate of lung disease (LD) in these patients. In this work, we aimed to characterise LD in AOSD, to identify associated clinical features and predictive factors, and to describe long-term outcomes of the disease comparing patients with LD and those without. ME...
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#1Aijing Liu (Hebei Medical University)H-Index: 5
#2Fu-Dong Shi (Barrow Neurological Institute)H-Index: 34
Last. Antonio La Cava (UCLA: University of California, Los Angeles)H-Index: 46
view all 7 authors...
BACKGROUND Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and abnormal immune responses to it in SLE, we investigated whether an HSP90 DNA vaccine could modulate the development and clinical manifestations of SLE in lupus-prone mice. METHODS (NZB x NZW)F1 (NZB/W) mice were vaccinated with DNA constructs encoding HSP90 or ...
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#1Tomohiro Shimizu (Hokkaido University)H-Index: 6
#2Shunichi Yokota (Hokkaido University)
Last. Daisuke Takahashi (Hokkaido University)H-Index: 8
view all 8 authors...
BACKGROUND There is evidence that the cause of primary osteoarthritis (OA) is related to the changes in subchondral bone; however, the influence of subchondral insufficiency fracture (SIF) of the femoral head on the degeneration of the hip joint and the prognostic factors related to joint degeneration remain unclear. The objectives of this study were (1) to investigate the natural history of joint space width after the occurrence of SIF and (2) to investigate the associations between joint space...
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#1Jun Inamo (Keio: Keio University)H-Index: 1
#2Katsuya Suzuki (Keio: Keio University)H-Index: 17
Last. Tsutomu TakeuchiTsukasa (Keio: Keio University)H-Index: 63
view all 10 authors...
BACKGROUND The aim of this study was to identify the molecular mechanism of dysregulation of B cell subpopulations of primary Sjogren's syndrome (pSS) at the transcriptome level. METHODS We enrolled patients with pSS (n = 6) and healthy controls (HCs) (n = 6) in the discovery cohort using microarray and pSS (n = 14) and HCs (n = 12) in the validation cohort using quantitative PCR (qPCR). Peripheral B cells acquired from these subjects were separated by cell sorting into four subsets: CD38-IgD+ (...
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#1Mingcan Yang (SYSU: Sun Yat-sen University)H-Index: 4
#2Q. Lv (SYSU: Sun Yat-sen University)H-Index: 6
Last. Zhiming Lin (SYSU: Sun Yat-sen University)H-Index: 12
view all 16 authors...
BACKGROUND Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, and the correlation between the efficacy of TNF-α inhibitor and changes in immune imbalance is unclear. METHODS A total of 40 immune cells were tested with flow cytometry, and the results of 105 healthy control (HC) subjects, 177 active-stage AS patients, and 23 AS cases before and after 12 weeks of TNF-α inhibitor therapy (Anbainuo) were analyzed. RESULTS Compared with the HC group,...
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#1Orthodoxia Nicolaou (The Cyprus Institute of Neurology and Genetics)H-Index: 1
#2Kleitos Sokratous (The Cyprus Institute of Neurology and Genetics)H-Index: 3
Last. George M. Spyrou (The Cyprus Institute of Neurology and Genetics)H-Index: 14
view all 16 authors...
BACKGROUND Approximately 50% of systemic lupus erythematosus (SLE) patients develop nephritis, which is among the most severe and frequent complications of the disease and a leading cause of morbidity and mortality. Despite intensive research, there are still no reliable lupus nephritis (LN) markers in clinical use that can assess renal damage and activity with a high sensitivity and specificity. To this end, the aim of this study was to identify new clinically relevant tissue-specific protein b...
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#1You Jung Ha (Yonsei University)H-Index: 12
#2Sun Mi Lee (Yonsei University)H-Index: 7
Last. YongBeom Park (Yonsei University)H-Index: 29
view all 10 authors...
BACKGROUNDS Despite the advances of rheumatoid arthritis (RA) therapeutics, several patients do not receive adequate treatment due to the toxicity and/or insufficient response of drugs. The aim of this study is to design photothermally controlled drug release from multifunctional nanoparticles (MNPs) at a near-infrared (NIR) irradiated site to improve therapeutic efficacy for RA and reduce side effects. METHODS Au film was deposited onto methotrexate (MTX)-loaded poly(ethylene glycol)-poly(lacti...
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Top fields of study
Rheumatology
Immunology
Arthritis
Rheumatoid arthritis
Diabetes mellitus
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