Peter M. Visscher
University of Queensland
Genome-wide association studyPopulationGeneticsLocus (genetics)Biology
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Publications 696
#1Baptiste Couvy-Duchesne (UQ: University of Queensland)H-Index: 11
#2Futao Zhang (UQ: University of Queensland)H-Index: 12
Last. Jian Yang (WMU: Wenzhou Medical College)H-Index: 113
view all 8 authors...
We evaluated the statistical power, family wise error rate (FWER) and precision of several competing methods that perform mass-univariate vertex-wise analyses of grey-matter (thickness and surface area). In particular, we compared several generalised linear models (GLMs, current state of the art) to linear mixed models (LMMs) that have proven superior in genomics. We used phenotypes simulated from real vertex-wise data and a large sample size (N=8,662) which may soon become the norm in neuroimag...
#1Sonia ShahH-Index: 36
#2Albert HenryH-Index: 1
Last. Mark ChaffinH-Index: 12
view all 202 authors...
#1Costanza L. Vallerga (UQ: University of Queensland)H-Index: 6
#2Futao Zhang (UQ: University of Queensland)H-Index: 12
Last. Leanne Wallace (UQ: University of Queensland)H-Index: 12
view all 30 authors...
An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age. We present results from a blood-based methylome-wide association study of PD involving meta-analysis of 229 K CpG probes in 1,132 cases and 999 controls from two independent cohorts. We identify two previously unreported epigenome-wide significant associations with PD, including cg06690548 on chromosome ...
#1Vincenzo Muto (University of Liège)H-Index: 11
#2Ekaterina Koshmanova (University of Liège)
Last. Marie BrandewinderH-Index: 2
view all 28 authors...
A bidirectional detrimental relationship between sleep alteration and Alzheimer9s disease (AD) has been reported in cognitively normal older adults. Here, we tested whether a similar association could be detected in young adults, decades before typical AD symptom onset. We investigated associations between sleep endophenotypes and genome-wide Polygenic Risk Scores (PRS) for AD in 363 young men (22.1 +/- 2.7y) devoid of sleep and cognitive disorders. AD PRS was associated with higher slow wave en...
#1Marta F. Nabais (UQ: University of Queensland)H-Index: 1
#1Marta F. Nabais (UQ: University of Queensland)
Last. Anna Freydenzon (UQ: University of Queensland)
view all 37 authors...
We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. We found a significantly higher proportion of neutrophils in cases compared to controls which replicated in an independent cohort from the Netherlands (1159 cases and 637 controls). The OSCA MOMENT linear mixed model has been shown i...
#1V. Kartik Chundru (UQ: University of Queensland)
#2Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
Last. Peter M. Visscher (UQ: University of Queensland)H-Index: 109
view all 12 authors...
Testing the effect of rare variants on phenotypic variation is difficult due to the need for extremely large cohorts to identify associated variants given expected effect sizes. An alternative approach is to investigate the effect of rare genetic variants on low-level genomic traits, such as gene expression or DNA methylation (DNAm), as effect sizes are expected to be larger for low-level compared to higher-order complex traits. Here, we investigate DNAm in healthy ageing populations - the Lothi...
#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Daniel Trejo-Banos (UNIL: University of Lausanne)
Last. David C. Liewald (Edin.: University of Edinburgh)H-Index: 37
view all 19 authors...
The molecular factors which control circulating levels of inflammatory proteins are not well understood. Furthermore, association studies between molecular probes and human traits are often performed by linear model-based methods which may fail to account for complex structure and interrelationships within molecular datasets. Therefore, in this study, we perform genome- and epigenome-wide association studies (GWAS/EWAS) on the levels of 70 plasma-derived inflammatory protein biomarkers in health...
#1Ying Wang (UQ: University of Queensland)H-Index: 1
#2Jian-ping Guo (UQ: University of Queensland)H-Index: 3
Last. Loic Yengo (UQ: University of Queensland)H-Index: 43
view all 6 authors...
Polygenic scores (PGS) have been widely used to predict complex traits and risk of diseases using variants identified from genome-wide association studies (GWASs). To date, most GWASs have been conducted in populations of European ancestry, which limits the use of GWAS-derived PGS in non-European populations. Here, we develop a new theory to predict the relative accuracy (RA, relative to the accuracy in populations of the same ancestry as the discovery population) of PGS across ancestries. We us...
#2Futao ZhangH-Index: 12
Last. Archie CampbellH-Index: 24
view all 22 authors...
#1Sonia Shah (UCL: University College London)H-Index: 36
#2Albert Henry (UCL: University College London)H-Index: 1
Last. R Thomas LumbersH-Index: 3
view all 146 authors...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one o...
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