Peter M. Visscher
University of Queensland
Genome-wide association studyPopulationGeneticsLocus (genetics)Biology
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Publications 715
#1Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 6
#2Futao Zhang (UQ: University of Queensland)H-Index: 16
Last. Riccardo E. MarioniH-Index: 45
view all 22 authors...
Availability of Data and Material According to the terms of consent for GS participants, access to individual-level data (omics and phenotypes) must be reviewed by the GS Access Committee. Applications should be made to Full summary statistics for the analyses presented are publicly available online at Funding GS received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the S...
2 CitationsSource
#1Angli Xue (UQ: University of Queensland)H-Index: 8
#2Londa Jiang (UQ: University of Queensland)
Last. Jian Yang (UQ: University of Queensland)H-Index: 96
view all 7 authors...
Genome-wide association studies (GWAS) have discovered numerous genetic variants associated with human behavioural traits. However, behavioural traits are subject to misreports and longitudinal changes (MLC) which can cause biases in GWAS and follow-up analyses. Here, we demonstrate that individuals with higher disease burden in the UK Biobank (n=455,607) are more likely to misreport or reduce their alcohol consumption (AC) levels, and propose a correction procedure to mitigate the MLC-induced b...
#1Daniel Trejo Banos (UNIL: University of Lausanne)H-Index: 1
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 6
Last. Archie Campbell (Edin.: University of Edinburgh)H-Index: 29
view all 23 authors...
Linking epigenetic marks to clinical outcomes improves insight into molecular processes, disease prediction, and therapeutic target identification. Here, a statistical approach is presented to infer the epigenetic architecture of complex disease, determine the variation captured by epigenetic effects, and estimate phenotype-epigenetic probe associations jointly. Implicitly adjusting for probe correlations, data structure (cell-count or relatedness), and single-nucleotide polymorphism (SNP) marke...
#1Hannes Svardal (University of Antwerp)H-Index: 10
#2Bosco Rusuwa (UNIMA: University of Malawi)H-Index: 8
Last. Cyprian Katongo (UNZA: University of Zambia)H-Index: 9
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: We report on the first meeting of SMBE in Africa. SMBE Malawi was initiated to bring together African and international researchers who use genetics or genomics to study natural systems impacted by human activities. The goals of this conference were (1) to reach a world class standard of science with a large number of contributions from within Africa, (2) to initiate an exchange between African and international researchers and (3) to identify challenges and opportunities for evolutionary geno...
#1Peter M. Visscher (UQ: University of Queensland)H-Index: 112
: The classical twin design relies on a number of strong number of assumptions in order to yield unbiased estimates of heritability. This includes the equal environments assumption - that monozygotic and dizygotic twins experience similar degrees of environmental similarity - an assumption that is likely to be violated in practice for many traits of interest. An alternative method of estimating heritability that does not suffer from many of these limitations is to model trait similarity between ...
#1Anke R. Hammerschlag (PHRI: Public Health Research Institute)
#2Enda M. Byrne (UQ: University of Queensland)H-Index: 35
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Abstract Background Recent genome-wide association studies (GWAS) identified the first genetic loci associated with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). The next step is to use these results to increase our understanding of the biological mechanisms involved. Most of the identified variants likely influence gene regulation. The aim of the current study is to shed light on the mechanisms underlying the genetic signals and prioritize genes by integrat...
#1Enda M. Byrne (UQ: University of Queensland)H-Index: 35
#2Zhihong Zhu (UQ: University of Queensland)H-Index: 21
Last. Michael John Owen (Cardiff University)H-Index: 142
view all 19 authors...
Substantial genetic liability is shared across psychiatric disorders but less is known about risk variants that are specific to a given disorder. We used multi-trait conditional and joint analysis (mtCOJO) to adjust GWAS summary statistics of one disorder for the effects of genetically correlated traits to identify putative disorder-specific SNP associations. We applied mtCOJO to summary statistics for five psychiatric disorders from the Psychiatric Genomics Consortium—schizophrenia (SCZ), bipol...
#1Robert F. HillaryH-Index: 4
#2Daniel Trejo BanosH-Index: 1
Last. David C. LiewaldH-Index: 39
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#1Robert F. HillaryH-Index: 4
#2Daniel Trejo BanosH-Index: 1
view all 19 authors...
#1Biaty RaymondH-Index: 2
#2Loic Yengo (UQ: University of Queensland)H-Index: 47
Last. Peter M. Visscher (UQ: University of Queensland)H-Index: 112
view all 8 authors...
Genome-Wide Association Studies (GWAS) in large human cohorts have identified thousands of loci associated with complex traits and diseases. For identifying the genes and gene-associated variants that underlie complex traits in livestock, especially where sample sizes are limiting, it may help to integrate the results of GWAS for equivalent traits in humans as prior information. In this study, we sought to investigate the usefulness of results from a GWAS on human height as prior information for...