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1985 in Journal of MarketingIF: 7.34
Ananthanarayanan Parasuraman59
Estimated H-index: 59
(Texas A&M University),
Valarie A. Zeithaml41
Estimated H-index: 41
(Texas A&M University),
Leonard L. Berry62
Estimated H-index: 62
(Texas A&M University)
The attainment of quality in products and services has become a pivotal concern of the 1980s. While quality in tangible goods has been described and measured by marketers, quality in services is largely undefined and unresearched. The authors attempt to rectify this situation by reporting the insights obtained in an extensive exploratory investigation of quality in four service businesses and by developing a model of service quality. Propositions and recommendations to stimulate future research ...
12.7k Citations Source Cite
Steffen Runge4
Estimated H-index: 4
,
Henning Thøgersen21
Estimated H-index: 21
+ 2 AuthorsRainer Rudolph35
Estimated H-index: 35
Abstract The glucagon-like peptide-1 receptor (GLP-1R) belongs to Family B1 of the seven-transmembrane G protein-coupled receptors, and its natural agonist ligand is the peptide hormone glucagon-like peptide-1 (GLP-1). GLP-1 is involved in glucose homeostasis, and activation of GLP-1R in the plasma membrane of pancreatic β-cells potentiates glucose-dependent insulin secretion. The N-terminal extracellular domain (nGLP-1R) is an important ligand binding domain that binds GLP-1 and the homologous ...
5,543 Citations Download PDF Cite
2003 in Journal of Cell ScienceIF: 4.40
Kylie J. Boyce13
Estimated H-index: 13
,
Michael J. Hynes26
Estimated H-index: 26
,
Alex Andrianopoulos30
Estimated H-index: 30
Rac proteins control polarized growth in many organisms but the specific function of these proteins remains undefined. In this study, we describe the cloning and functional characterization of a RAC homolog, cflB , from the dimorphic fungus Penicillium marneffei. P. marneffei produces asexual spores on complex structures (conidiophores) and switches between hyphal and yeast growth. CflB colocalizes with actin at the tips of vegetative hyphal cells and at sites of cell division. Deletion of cflB ...
3,145 Citations Download PDF Cite
2007 in NatureIF: 41.58
Nick Barker55
Estimated H-index: 55
,
Johan H. van Es47
Estimated H-index: 47
+ 8 AuthorsHans Clevers152
Estimated H-index: 152
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently believed that four to six crypt stem cells reside at the +4 position immediately above the Paneth cells in the small intestine; colon stem cells remain undefined. Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5, also known as Gpr49) was selected from a panel of intestinal Wnt target genes for its restricted crypt expression. Here, using two knock-in alleles, we reveal exclusive ...
2,824 Citations Download PDF Cite
2001 in NatureIF: 41.58
Masamitsu Nakazato71
Estimated H-index: 71
,
Noboru Murakami38
Estimated H-index: 38
+ 4 AuthorsShigeru Matsukura52
Estimated H-index: 52
Ghrelin is an acylated peptide that stimulates the release of growth hormone from the pituitary'. Ghrelin-producing neurons are located in the hypothalamus, whereas ghrelin receptors are expressed in various regions of the brain 2-4 , which is indicative of central-and as yet undefined-physiological functions. Here we show that ghrelin is involved in the hypothalamic regulation of energy homeostasis. Intracerebroventricular injections of ghrelin strongly stimulated feeding in rats and increased ...
2,722 Citations Download PDF Cite
Stan Gronthos63
Estimated H-index: 63
(National Institutes of Health),
Mahesh H. Mankani22
Estimated H-index: 22
(National Institutes of Health)
+ 2 AuthorsSongtao Shi71
Estimated H-index: 71
(National Institutes of Health)
Dentinal repair in the postnatal organism occurs through the activity of specialized cells, odontoblasts, that are thought to be maintained by an as yet undefined precursor population associated with pulp tissue. In this study, we isolated a clonogenic, rapidly proliferative population of cells from adult human dental pulp. These DPSCs were then compared with human bone marrow stromal cells (BMSCs), known precursors of osteoblasts. Although they share a similar immunophenotype in vitro , functio...
2,543 Citations Download PDF Cite
2003 in JAMAIF: 47.66
Margaret May Redfield88
Estimated H-index: 88
,
Steven J. Jacobsen54
Estimated H-index: 54
+ 3 AuthorsRichard J. Rodeheffer64
Estimated H-index: 64
ContextApproximately half of patients with overt congestive heart failure (CHF) have diastolic dysfunction without reduced ejection fraction (EF). Yet, the prevalence of diastolic dysfunction and its relation to systolic dysfunction and CHF in the community remain undefined.ObjectivesTo determine the prevalence of CHF and preclinical diastolic dysfunction and systolic dysfunction in the community and determine if diastolic dysfunction is predictive of all-cause mortality.Design, Setting, Partici...
2,203 Citations Source Cite
Timothy J. Ley80
Estimated H-index: 80
(Washington University in St. Louis),
Christopher A. Miller39
Estimated H-index: 39
(Washington University in St. Louis)
+ 136 AuthorsRichard Wilson145
Estimated H-index: 145
(Washington University in St. Louis)
BACKGROUND—Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear. METHODS—We analyzed the genomes of 200 clinically annotated adult cases of de novo AML, using either whole-genome sequencing (50 cases) or whole-exome sequencing (150 cases), along with RNA and microRNA sequencing and DNA-methylation analysis. RESULTS—AML genomes have fewer mutations than most oth...
1,611 Citations Download PDF Cite
2002 in NatureIF: 41.58
Yasuhiko Minokoshi39
Estimated H-index: 39
(Beth Israel Deaconess Medical Center),
Young-Bum Kim47
Estimated H-index: 47
(Beth Israel Deaconess Medical Center)
+ 4 AuthorsBarbara B. Kahn95
Estimated H-index: 95
(Beth Israel Deaconess Medical Center)
Abstract Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of fatty acids and the uptake of glucose, and prevents the accumulation of lipids in nonadipose tissues, which can lead to functional impairments known as "lipotoxicity". The signalling pathways that mediate the metabolic effects of leptin remain undefined. The 5'-AMP-activated protein kinase (AMPK) potently stimu...
1,567 Citations Download PDF Cite
2005 in CellIF: 31.40
Sarkis K. Mazmanian51
Estimated H-index: 51
(Harvard University),
Cui Hua Liu15
Estimated H-index: 15
(Southern Medical University)
+ 1 AuthorsDennis L. Kasper78
Estimated H-index: 78
(Harvard University)
Summary The mammalian gastrointestinal tract harbors a complex ecosystem consisting of countless bacteria in homeostasis with the host immune system. Shaped by evolution, this partnership has potential for symbiotic benefit. However, the identities of bacterial molecules mediating symbiosis remain undefined. Here we show that, during colonization of animals with the ubiquitous gut microorganism Bacteroides fragilis , a bacterial polysaccharide (PSA) directs the cellular and physical maturation o...
1,487 Citations Download PDF Cite