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Published on May 1, 2016in Trends in Cardiovascular Medicine 4.60
Scott M. Grundy163
Estimated H-index: 163
(University of Texas Southwestern Medical Center)
The metabolic syndrome is a multiplex risk factor for atherosclerotic cardiovascular disease and type 2 diabetes. It is composed of atherogenic dyslipidemia, elevated blood pressure, insulin resistance and elevated glucose, a pro-thrombotic state, and a pro-inflammatory state. Excess energy intake and concomitant obesity are the major drivers of the syndrome. Lifestyle intervention can reverse metabolic risk factors, but at times, drug therapies or bariatric surgery m...
106 Citations Source Cite
Published on Dec 1, 2005in The Lancet 53.25
Robert H. Eckel95
Estimated H-index: 95
(University of Colorado Denver),
K. G. M. M. Alberti38
Estimated H-index: 38
(Imperial College London)
+ 0 AuthorsPaul Zimmet102
Estimated H-index: 102
(Baker IDI Heart and Diabetes Institute)
The National Cholesterol Education Program’s Adult Treatment Panel III (ATP III) report [1] added the metabolic syndrome, a multidimensional risk factor for cardiovascular disease (CVD), as a coequal partner of elevated low-density lipoprotein (LDL) cholesterol for risk-reduction therapies. Interest in the metabolic syndrome has increased greatly since the publication of the ATP III report. There are several aspects to the metabolic syndrome that deserve...
5,097 Citations Source Cite
Published on Feb 1, 2015in The Lancet Diabetes & Endocrinology 19.31
Markus P. Schlaich55
Estimated H-index: 55
(Monash University),
Nora E. Straznicky32
Estimated H-index: 32
(Baker IDI Heart and Diabetes Institute)
+ 1 AuthorsGavin W. Lambert67
Estimated H-index: 67
(Monash University)
Summary Metabolic syndrome is associated with adverse health outcomes and is a growing problem worldwide. Although efforts to harmonise the definition of metabolic syndrome have helped to better understand the prevalence and the adverse outcomes associated with the disorder on a global scale, the mechanisms underpinning the metabolic changes that define it are incompletely understood. Accumulating evidence from laboratory and human studies suggests that activat...
39 Citations Source Cite
Published on Nov 1, 2014in Nature Reviews Rheumatology 15.66
György Kerekes16
Estimated H-index: 16
(University of Debrecen),
Michael T. Nurmohamed38
Estimated H-index: 38
(VU University Amsterdam)
+ 7 AuthorsZoltán Szekanecz54
Estimated H-index: 54
(University of Debrecen)
Rheumatoid arthritis (RA) and metabolic syndrome share several pathologic characteristics, such as changes in body composition, lipid levels and insulin sensitivity, that may increase cardiovascular mortality. Here, Kerekes and co-authors discuss associations between these components in RA and metabolic syndrome and propose that optimal therapeutic control of RA might attenuate adverse effects of metabolic syndrome in patients with RA.
52 Citations Source Cite
Published on Dec 1, 2014in Reviews in Endocrine & Metabolic Disorders 4.96
Nora Klöting38
Estimated H-index: 38
(Leipzig University),
Matthias Blüher73
Estimated H-index: 73
(Leipzig University)
Obesity is frequently associated with chronic inflammation, metabolic and vascular alterations which predispose to the development of the Metabolic Syndrome (MetS). However, the individual obesity-related risk for the MetS is not determined by increased fat mass alone. Heterogeneity of body composition, fat distribution and adipose tissue (AT) function may underly the variable risk to develop metabolic and cardiovascular diseases associated with increased body fat mas...
129 Citations Source Cite
Published on Dec 1, 2006in Nature 41.58
Jean-Pierre Després109
Estimated H-index: 109
(Laval University),
Isabelle Lemieux44
Estimated H-index: 44
Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. Proposed criteria for identifying patients with metabolic syndrome have contributed greatly to preventive medicine, but the value of metabolic syndrome as a scientific concept remains controversial. The presence of metabolic syndrome alone cannot pre...
2,590 Citations Source Cite
Published on Dec 1, 2014in Reviews in Endocrine & Metabolic Disorders 4.96
Alena Stančáková42
Estimated H-index: 42
(University of Eastern Finland),
Markku Laakso74
Estimated H-index: 74
(University of Eastern Finland)
Metabolic syndrome (MetS) is a cluster of metabolic traits associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. Central obesity and insulin resistance are thought to play key roles in the pathogenesis of the MetS. The MetS has a significant genetic component, and therefore linkage analysis, candidate gene approach, and genome-wide association (GWA) studies have been applied in the search of gene variants for the MetS. A few variants have ...
27 Citations Source Cite
Mohsen Mazidi18
Estimated H-index: 18
(Chinese Academy of Sciences),
Peyman Rezaie9
Estimated H-index: 9
+ 2 AuthorsGordon A. Ferns35
Estimated H-index: 35
(Brighton and Sussex Medical School)
Abstract The gut microbiome contributes approximately 2 kg of the whole body weight, and recent studies suggest that gut microbiota has a profound effect on human metabolism, potentially contributing to several features of the metabolic syndrome. Metabolic syndrome is defined by a clustering of metabolic disorders that include central adiposity with visceral fat accumulation, dyslipidemia, insulin resistance, dysglycemia and non-optimal blood pressure levels. <...
31 Citations Source Cite
Dorit Koren9
Estimated H-index: 9
Magdalena Dumin1
Estimated H-index: 1
David Gozal86
Estimated H-index: 86
Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literat...
37 Citations Source Cite
Published on Dec 1, 2014in Reviews in Endocrine & Metabolic Disorders 4.96
Soo Lim40
Estimated H-index: 40
(Seoul National University Bundang Hospital),
Robert H. Eckel95
Estimated H-index: 95
(Anschutz Medical Campus)
Metabolic syndrome is a disorder based on insulin resistance. Metabolic syndrome is diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal obesity, elevated blood pressures, elevated glucose, high triglycerides, and low high-density lipoprotein-cholesterol (HDL-C) levels. Clinical implication of metabolic syndrome is that it increases the risk of developing type 2 diabetes and cardiovascular diseases. Prevalence ...
32 Citations Source Cite