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Published on Jun 4, 2015in The New England Journal of Medicine 79.26
J. Larry Jameson59
Estimated H-index: 59
Dan L. Longo106
Estimated H-index: 106
This article considers the growing recognition of precision medicine by clinicians, patients, the pharmaceutical industry, and policymakers and summarizes how this rapidly accelerating field will leave a major imprint on the practice of medicine.
324 Citations Source Cite
Published on Dec 1, 2016in Genome Medicine 8.90
Charles Auffray41
Estimated H-index: 41
(University of Lyon),
Timothy Caulfield34
Estimated H-index: 34
(University of Alberta)
+ 3 AuthorsMatthias Schwab82
Estimated H-index: 82
(University of Tübingen)
2015 has been an exciting year for genomic medicine. We asked our Section Editors to discuss the breakthroughs in their fields of expertise, and what these might mean for the future. As in previous years, exome and whole-genome sequencing are leading the way in our understanding of disease mechanisms, their diagnosis and treatment, while information about the protein products of the genome has also grown, driven by novel technological advances. Precision medicine is now taking off ...
14 Citations Source Cite
Published on Nov 1, 2014in JAMA Internal Medicine 19.99
Michael B. Rothberg36
Estimated H-index: 36
(Cleveland Clinic),
Joshua Class1
Estimated H-index: 1
(Howard University)
+ 3 AuthorsPeter K. Lindenauer42
Estimated H-index: 42
(Baystate Medical Center)
The overuse of tests and procedures due to fear of malpractice litigation, known as defensive medicine,1 is estimated to cost $46 billion annually in the US,2 but these costs have been measured only indirectly. We estimated the cost of defensive medicine on three hospital medicine services in a health system by having physicians assess the defensiveness of their own orders. We hypothesized that physicians who were concerned about being targeted by litigation would practice m...
19 Citations Source Cite
Published on Jan 1, 2016in Stem Cells Translational Medicine 4.93
Ann Tsukamoto1
Estimated H-index: 1
Stewart E. Abbot1
Estimated H-index: 1
+ 5 AuthorsMichael J. Werner2
Estimated H-index: 2
The aging population in the U.S. and other developed countries has led to a large increase in the number of patients suffering from degenerative diseases. Transplantation surgery has been a successful therapeutic option for certain patients; however, the availability of suitable donor organs and tissues significantly limits the number of patients who can benefit from this approach. Regenerative medicine has witnessed numerous recent and spectacular advances, making the repair or replaceme...
36 Citations Source Cite
Published on Nov 1, 2017in The American Journal of Medicine 5.12
Ralph I. Horwitz4
Estimated H-index: 4
(Temple University),
Allison Hayes-Conroy8
Estimated H-index: 8
(Temple University)
+ 1 AuthorsBurton H. Singer73
Estimated H-index: 73
(University of Florida)
Abstract Evidence based medicine, using randomized controlled trials and meta-analyses as the major tools and sources of evidence about average results for heterogeneous groups of patients, developed as a reaction against poorly designed observational treatment research and physician reliance on personal experience with other patients as a guide to decision-making about a patient at hand. However, these tools do not answer the clinician's question: "Will a given therapeutic regimen help m...
9 Citations Source Cite
Published on Jan 1, 2014in Genome Medicine 8.90
Olaf Wolkenhauer33
Estimated H-index: 33
(University of Rostock),
Charles Auffray41
Estimated H-index: 41
(University of Lyon)
+ 17 AuthorsHelen M. Byrne33
Estimated H-index: 33
(University of Oxford)
CITATION: Wolkenhauer, O. et al. 2014. Enabling multiscale modeling in systems medicine. Genome Medicine, 6:21, doi:10.1186/gm538.
43 Citations Source Cite
Published on Dec 1, 2015in Stem Cells Translational Medicine 4.93
Andre Terzic74
Estimated H-index: 74
(Mayo Clinic),
Michael A. Pfenning12
Estimated H-index: 12
(Mayo Clinic)
+ 1 AuthorsC. Michel Harper26
Estimated H-index: 26
(Mayo Clinic)
Regenerative technologies strive to boost innate repair processes and restitute normative impact. Deployment of regenerative principles into practice is poised to usher in a new era in health care, driving radical innovation in patient management to address the needs of an aging population challenged by escalating chronic diseases. There is urgency to design, execute, and validate viable paradigms for translating and implementing the science of regenerative medicine into tangible health b...
16 Citations Source Cite
Published on Mar 2, 2018in Experimental and Molecular Medicine 5.58
Rolf Apweiler48
Estimated H-index: 48
Tim Beissbarth30
Estimated H-index: 30
(University of Göttingen)
+ 29 AuthorsOlaf Wolkenhauer33
Estimated H-index: 33
(University of Rostock)
Creating specialised computer systems to integrate big data from multiple sources may help provide tailored future healthcare. A healthcare system that meets the needs of every individual needs the ability to collect and mine data precisely and efficiently. Olaf Wolkenhauer at Rostock University, Germany and co-workers have explored the requirements for developing this ‘systems medicine’ approach. Interdisciplinary teams should be established specifically to develop software, computationa...
4 Citations Source Cite
Published on Jan 1, 2016in The Lancet Respiratory Medicine 21.47
Geraint B. Rogers30
Estimated H-index: 30
(Flinders University),
Steve Wesselingh6
Estimated H-index: 6
(Flinders University)
Summary A decade of rapid technological advances has provided an exciting opportunity to incorporate information relating to a range of potentially important disease determinants in the clinical decision-making process. Access to highly detailed data will enable respiratory medicine to evolve from one-size-fits-all models of care, which are associated with variable clinical effectiveness and high rates of side-effects, to precision approaches, where treatment is tailored to individual pat...
13 Citations Source Cite
Published on Feb 23, 2012in The New England Journal of Medicine 79.26
Elizabeth G. Phimister8
Estimated H-index: 8
W. Gregory Feero14
Estimated H-index: 14
Alan E. Guttmacher16
Estimated H-index: 16
The current series of Genomic Medicine review articles concludes in this issue of the Journal with the publication of an article on cognitive impairment and autism by Mefford and colleagues.1 The topic of this article is an appropriate capstone for the Genomic Medicine series: it highlights the clinical advances in genomics regarding the care of patients with neurologic conditions, and it shows the potential of genomic science to further accelerate the pace of discovery in the neur...
46 Citations Source Cite