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Sherry G. Lin2
Estimated H-index: 2
(Harvard University),
Chunguang Guo9
Estimated H-index: 9
+ 2 AuthorsFrederick W. Alt153
Estimated H-index: 153
(Harvard University)
Mice and humans generate diverse antibody repertoires through a genomic rearrangement process termed “V(D)J recombination” that assembles genetic regions that encode antigen-binding portions of antibodies by cutting and pasting together different combinations of V, D, and J gene segments. V(D)J recombination is strictly controlled to ensure generating a sufficiently large antibody repertoire to recognize any pathogen encountered and to minimize generation of self-reactive antibodies. Across the ...
37 Citations Download PDF Cite
Ralph Stadhouders17
Estimated H-index: 17
(Erasmus University Medical Center),
Suleyman Aktuna1
Estimated H-index: 1
+ 10 AuthorsEric Soler19
Estimated H-index: 19
(French Alternative Energies and Atomic Energy Commission)
Genetic studies have identified common variants within the intergenic region (HBS1L-MYB) between GTP-binding elongation factor HBS1L and myeloblastosis oncogene MYB on chromosome 6q that are associated with elevated fetal hemoglobin (HbF) levels and alterations of other clinically important human erythroid traits. It is unclear how these noncoding sequence variants affect multiple erythrocyte characteristics. Here, we determined that several HBS1L-MYB intergenic variants aff...
79 Citations Download PDF Cite
2015 in OncogeneIF: 6.85
Cheng-Zhong Zhang16
Estimated H-index: 16
,
Sergio Casas-Tinto11
Estimated H-index: 11
+ 5 AuthorsL Zhou1
Estimated H-index: 1
An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasia
8 Citations Source Cite
2014 in BloodIF: 15.13
Tasha Morrison2
Estimated H-index: 2
(Boston University),
Ibi Wilcox (Boston University)+ 2 AuthorsDavid H.K. Chui36
Estimated H-index: 36
(Boston University)
Fetal hemoglobin (HbF, α 2 γ 2 ) is the main hemoglobin in the fetus, but its levels decline after birth to HBS1L-MYB intergenic region (Farrell et al, Blood 2011 ) and this work has been recently confirmed (Stadhouders et al, JCI , 2014). This deletion was found to be in strong linkage disequilibrium (LD) with the QTL HMIP, the HBS1L-MYB intergenic region on chr6q23. Functional analyses of the region around the 3-bp deletion using ChIP assay in K562 cells, whi...
2018 in Pediatric ResearchIF: 3.12
Tamas Jilling31
Estimated H-index: 31
(University of Alabama at Birmingham),
Namasivayam Ambalavanan44
Estimated H-index: 44
(University of Alabama at Birmingham)
+ 5 AuthorsGrier P. Page44
Estimated H-index: 44
(RTI International)
Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome eight
4 Citations Source Cite
Noël Tordo41
Estimated H-index: 41
,
Olivier Poch53
Estimated H-index: 53
+ 2 AuthorsF Rougeon1
Estimated H-index: 1
Abstract Rabies cDNA clones, obtained by "walking along the genome" using two successive DNA primers, have allowed the sequence determination of the genes encoding the N, M1, M2, G, and the beginning of the L protein as well as the rabies intergenic regions. Start and stop transcription signals located at the border of each gene encoding a protein have been identified and are similar to the corresponding signals from vesicular stomatitis virus (VSV) and Sendai virus. Except for limited st...
294 Citations Download PDF Cite
Amity R. Roberts4
Estimated H-index: 4
(University of Oxford),
Matteo Vecellio10
Estimated H-index: 10
(University of Oxford)
+ 6 AuthorsB P Wordsworth11
Estimated H-index: 11
(University of Oxford)
Objectives To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R - IL12RB2 intergenic region. Methods We performed conditional analysis on genetic association data and used epigenetic data on chromatin remodelling and transcription factor (TF) binding to identify the primary AS-associated IL23R-IL12RB2 intergenic SNP. Functional effects were tested in luciferase reporter assays in HEK29...
11 Citations Download PDF Cite
Zhenling Cui8
Estimated H-index: 8
(Tongji University),
Yuanyuan Li2
Estimated H-index: 2
(Tongji University)
+ 4 AuthorsBaoxue Ge23
Estimated H-index: 23
(Tongji University)
The rapid increase in Mycobacterium tuberculosis resistance to ethambutol (EMB) threatens the diagnosis and treatment of tuberculosis (TB). We investigated the role of mutations in the embC-embA intergenic region (IGR) in EMB-resistant clinical strains from east China. A total of 767 M. tuberculosis clinical strains were collected and analyzed for their drug susceptibility to EMB using the MGIT 960 system and MIC assay, and the embC-embA IGRs of these strains were sequenced. The tr...
16 Citations Download PDF Cite
2015 in The Plant CellIF: 8.23
Akiko Maruyama-Nakashita11
Estimated H-index: 11
(Fukui Prefectural University),
Akiko Watanabe-Takahashi13
Estimated H-index: 13
+ 3 AuthorsHideki Takahashi36
Estimated H-index: 36
(Michigan State University)
Under sulfur deficiency (−S), plants induce expression of the sulfate transport systems in roots to increase uptake and root-to-shoot transport of sulfate. The low-affinity sulfate transporter SULTR2;1 is predominantly expressed in xylem parenchyma and pericycle cells in Arabidopsis thaliana roots under –S. The mechanisms underlying –S-inducible expression of SULTR2;1 in roots have remained unclear, despite the possible significance of SULTR2;1 for acclimation to low-sulfur conditions. In this i...
23 Citations Download PDF Cite
Cyril Cyrus4
Estimated H-index: 4
,
Chittibabu Vatte4
Estimated H-index: 4
+ 10 AuthorsAmein Al Ali3
Estimated H-index: 3
Background and Objectives. β-Thalassemia and sickle cell disease are genetic disorders characterized by reduced and abnormal β-globin chain production, respectively. The elevation of fetal hemoglobin (HbF) can ameliorate the severity of these disorders. In sickle cell disease patients, the HbF level elevation is associated with three quantitative trait loci (QTLs), BCL11A, HBG2 promoter, and HBS1L-MYB intergenic region. This study elucidates the existence of the variants in these t...
2 Citations Download PDF Cite