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2012 in Brain [IF: 10.29]
María García-Murias3
Estimated H-index: 3
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Beatriz Quintáns14
Estimated H-index: 14
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Arias M10
Estimated H-index: 10
... more
Spinocerebellar ataxia 36 has been recently described in Japanese families as a new type of spinocerebellar ataxia with motor neuron signs. It is caused by a GGCCTG repeat expansion in intron 1 of NOP56 . Family interview and document research allowed us to reconstruct two extensive, multigenerational kindreds stemming from the same village (Costa da Morte in Galicia, Spain), in the 17th century. We found the presence of the spinocerebellar ataxia 36 mutation co-segregating with disease i...
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Ignacio Rego9
Estimated H-index: 9
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M. Fernández-Moreno9
Estimated H-index: 9
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Carlos Fernández-López14
Estimated H-index: 14
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Objective: To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population. Methods: mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking. Results: Individuals carrying haplogr...
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Francesca Conti2
Estimated H-index: 2
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Saul Oswaldo Lugo-Reyes1
Estimated H-index: 1
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Lizbeth Blancas Galicia2
Estimated H-index: 2
... more
Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by inborn errors of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex. From the first year of life onward, most affected patients display multiple, severe, and recurrent infections caused by bacteria and fungi. Mycobacterial infections have also been reported in some patients. Objective Our objective was to assess the effect of mycobacterial disease in patients with CGD. Methods We an...
Ref 53Cited 22
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Background There is a debate whether axial psoriatic arthritis (axPsA) is an ankylosing spondylitis with psoriasis, however due to the fact that PsA has characteristic clinical features, this concept is debatable. On the other hand HLA-B27 is a key component of the clinical arm of the new ASAS criteria for axial SpA Objectives To determine the prevalence of HLA-B27 in PsA and to analyze its prevalence according to the clinical forms Methods Cross-sectional prevalence study o...
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M. Camacho Encina , V. Calamia1
Estimated H-index: 1
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F. Picchi ... more
Background The immune system can detect the changes involved in the osteoarthitic (OA) joint, triggering the production of immunoglobulins against self-proteins (Autoantibodies or AAbs). As AAbs might be generated in a stage prior to the disease, they can be potentially used to identify an increased risk for the disorder, allowing the diagnosis of asymptomatic OA. Objectives The discovery of an AAb signature useful for the early diagnosis of knee OA. Methods Nucleic Acid-Programmable Protein Arr...
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2016 in Journal of Clinical Oncology [IF: 24.01]
Claudia Arce-Salinas4
Estimated H-index: 4
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Gabriela Alamilla , Diana flores-Diaz1
Estimated H-index: 1
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579Background: Obesity and overweight are risk factors for breast cancer development and increase mortality; several pathophysiological mechanisms are involved, mainly are, the release from the fat tissue of pro-inflammatory substances, activation pathways related to cell proliferation and decreased apoptosis promoted by insulin and IGF-1 and estradiol dysregulation. It has been demostrated that metformin improves breast cancer outcomes. The aim of this is study is to evaluate the efficacy in te...
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2011 in Journal of Clinical Oncology [IF: 24.01]
H. C. Arce Salinas , Rebeca Ramirez-Morales1
Estimated H-index: 1
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Christian Aguila2
Estimated H-index: 2
... more
134 Background: Breast cancer in older women has a tendency to increase its incidence; the prevalence and their clinical course are not reported. This group of patients is usually considered to be fragile; they receive dose levels of chemotherapy below standards. Objective: To compare the association of dose intensity with complete pathological response (cPR) in older women. Methods: This is a retrospective analysis of patients treated with neoadjuvant anthracyclines, taxanes, or combinat...
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156 Background: Breast cancer is the leading cause of attention at the INCan. In 2012, 44,761 medical consults were given therefore 19,584 (44%) of those by breast cancer oncologists. The increasing percentage of patients could be associated with a quality attention deficit, crowded waiting room and a shorter time for consultations affecting patient communication and education. The goal of this study was to evaluate the quality attention given by breast cancer service with the purpose to design ...
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