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Published on Mar 1, 2016in Cell Metabolism 20.57
Daniel J. Rader131
Estimated H-index: 131
(University of Pennsylvania)
Dyslipidemia is a risk factor for atherosclerotic cardiovascular disease (ASCVD). Abundant data indicate that low-density lipoproteins (LDL) are causal for ASCVD; a new class of LDL-lowering medicines, the PCSK9 inhibitors, will address much unmet medical need. Human genetics suggest that triglyceride-rich lipoproteins (TRL) are pro-atherogenic and have pointed to a number of protein regulators of lipoprotein lipase activity that are candidates for therapeutic targeting. Finally, high-den...
28 Citations Source Cite
Published on Feb 4, 2014in Circulation 18.88
Ariel T.H. Frank3
Estimated H-index: 3
(Palo Alto Medical Foundation),
Beinan Zhao5
Estimated H-index: 5
(Palo Alto Medical Foundation)
+ 3 AuthorsLatha Palaniappan33
Estimated H-index: 33
(Palo Alto Medical Foundation)
Background—No studies have comprehensively examined the prevalence of dyslipidemia, a major risk factor for cardiovascular disease, among diverse racial/ethnic minority groups. The primary aim of this study was to identify racial/ethnic differences in dyslipidemia among minorities including Asian Americans (Asian Indian, Chinese, Filipino, Japanese, Korean, or Vietnamese), Mexican Americans, and blacks compared with non-Hispanic whites. Methods and Results—Using a 3-year cross sect...
49 Citations Source Cite
Published on Aug 1, 2016in Metabolism-clinical and Experimental 5.96
Niki Katsiki29
Estimated H-index: 29
(Aristotle University of Thessaloniki),
Dimitri P. Mikhailidis57
Estimated H-index: 57
(University College London),
Christos S. Mantzoros100
Estimated H-index: 100
(Beth Israel Deaconess Medical Center)
Abstract Non-alcoholic fatty liver (NAFLD) is the most common liver disease worldwide, progressing from simple steatosis to necroinflammation and fibrosis (leading to non-alcoholic steatohepatitis, NASH), and in some cases to cirrhosis and hepatocellular carcinoma. Inflammation, oxidative stress and insulin resistance are involved in NAFLD development and progression. NAFLD has been associated with several cardiovascular (CV) risk factors including obesity, dyslipidemia, hyperglycemia, hy...
70 Citations Source Cite
Published on Sep 1, 2014in Journal of Clinical Lipidology 3.58
Terry A. Jacobson57
Estimated H-index: 57
(Emory University),
Matthew K. Ito17
Estimated H-index: 17
(Oregon Health & Science University)
+ 9 AuthorsW. Virgil Brown26
Estimated H-index: 26
(Emory University)
Various organizations and agencies have issued recommendations for the management of dyslipidemia. Although many commonalities exist among them, material differences are present as well. The leadership of the National Lipid Association (NLA) convened an Expert Panel to develop a consensus set of recommendations for patient-centered management of dyslipidemia in clinical med- icine. The current Executive Summary highlights the major conclusions in Part 1 of the recommenda- tions rep...
321 Citations Source Cite
Published on Apr 1, 2016in Seminars in Arthritis and Rheumatism 4.36
Konstantinos Tselios4
Estimated H-index: 4
(University Health Network),
Charalambos Koumaras1
Estimated H-index: 1
+ 1 AuthorsMurray B. Urowitz71
Estimated H-index: 71
(University Health Network)
Abstract Objective Among traditional atherosclerotic risk factors, dyslipidemia is believed to decisively affect the long-term prognosis of lupus patients, not only with regard to cardiovascular events but also by influencing other manifestations, such as lupus nephritis. The aim of this study was to review the epidemiology, pathogenesis, evidence for its impact on atherosclerosis manifestations and management of dyslipidemia in lupus patients. Methods English-restricted MEDLINE da...
24 Citations Source Cite
Published on Apr 21, 2010in JAMA 47.66
Jean A. Welsh15
Estimated H-index: 15
Andrea Sharma1
Estimated H-index: 1
(Emory University)
+ 3 AuthorsMiriam B. Vos25
Estimated H-index: 25
(Emory University)
Context Dietary carbohydrates have been associated with dyslipidemia, a lipid profile known to increase cardiovascular disease risk. Added sugars (caloric sweeteners used as ingredients in processed or prepared foods) are an increasing and potentially modifiable component in the US diet. No known studies have examined the association between the consumption of added sugars and lipid measures. Objective To assess the association between consumption of added sugars and blood lipid levels in...
192 Citations Source Cite
Published on Apr 1, 2015in Atherosclerosis 4.47
Marja-Riitta Taskinen87
Estimated H-index: 87
(University of Helsinki),
Jan Borén63
Estimated H-index: 63
(Sahlgrenska University Hospital)
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality for patients with type 2 diabetes, despite recent significant advances in management strategies to lessen CVD risk factors. A major cause is the atherogenic dyslipidemia, which consists of elevated plasma concentrations of both fasting and postprandial triglyceride-rich lipoproteins (TRLs), small dense low-density lipoprotein (LDL) and low high-density lipoprotein (HDL) cholesterol. The different components ...
112 Citations Source Cite
Published on Jan 1, 2014in Advances in Clinical Chemistry 4.25
Hua Chen19
Estimated H-index: 19
(Chinese Ministry of Education),
Hua Miao10
Estimated H-index: 10
(Chinese Ministry of Education)
+ 2 AuthorsRui-Chao Lin29
Estimated H-index: 29
(Beijing University of Chinese Medicine)
Abstract Hyperlipidemia is an important public health problem with increased incidence and prevalence worldwide. Current clinical biomarkers, triglyceride, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol lack the necessary specificity and sensitivity and only increase significantly after serious dyslipidemia. Therefore, sensitive biomarkers are needed for hyperlipidemia. Hyperlipidemia-specific biomarkers would improve clinical diagnosis an...
32 Citations Source Cite
Published on Sep 1, 2015in Journal of Clinical Lipidology 3.58
Stephen R. Daniels122
Estimated H-index: 122
(University of Colorado Denver)
Clinical guidelines are developed to assist clinicians in complex clinical decision making. Modern guideline development includes a systematic review and grading of relevant literature and then using the evidence review to construct recommendations for clinical care which are also graded regarding the level of evidence supporting them. Pediatric guidelines for dyslipidemia were first published in 1992. There was then a gap during which no formal guidelines were developed. In 2011, the Nat...
3 Citations Source Cite
Published on Feb 1, 1990in Diabetes Care 13.40
Abhimanyu Garg68
Estimated H-index: 68
Scott M. Grundy163
Estimated H-index: 163
Coronary heart disease is the leading cause of death among patients with non-insulin-dependent diabetes mellitus (NIDDM). NIDDM patients have a high frequency of dyslipidemia, which along with obesity, hypertension, and hyperglycemia may contribute significantly to accelerated coronary atherosclerosis. Because risk factors for coronary heart disease are additive and perhaps multiplicative, even mild degrees of dyslipidemia may enhance coronary heart disease risk. Therefore, therape...
208 Citations Source Cite