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Published on Jun 15, 2017in The New England Journal of Medicine 79.26
David G. Armstrong88
Estimated H-index: 88
,
Andrew J.M. Boulton84
Estimated H-index: 84
,
Sicco A. Bus29
Estimated H-index: 29
(University of Amsterdam)
Foot ulceration is the most common lower-extremity complication in patients with diabetes mellitus. This review considers the pathogenesis, treatment, and management of diabetic foot ulcers, including prevention of recurrence.
113 Citations Source Cite
Published on Nov 1, 2005in The Lancet 53.25
Andrew J.M. Boulton84
Estimated H-index: 84
(University of Manchester),
Loretta Vileikyte24
Estimated H-index: 24
(University of Manchester)
+ 1 AuthorsJan Apelqvist53
Estimated H-index: 53
(Lund University)
Diabetic foot problems are common throughout the world, resulting in major economic consequences for the patients, their families, and society. Foot ulcers are more likely to be of neuropathic origin, and therefore eminently preventable, in developing countries, which will experience the greatest rise in the prevalence of type 2 diabetes in the next 20 years. People at greatest risk of ulceration can easily be identified by careful clinical examination of the feet: education...
1,152 Citations Source Cite
Published on May 1, 2003in The Lancet 53.25
William Jeffcoate43
Estimated H-index: 43
(University of Nottingham),
Keith Harding6
Estimated H-index: 6
(University of Wales)
Summary Ulceration of the foot in diabetes is common and disabling and frequently leads to amputation of the leg. Mortality is high and healed ulcers often recur. The pathogenesis of foot ulceration is complex, clinical presentation variable, and management requires early expert assessment. Interventions should be directed at infection, peripheral ischaemia, and abnormal pressure loading caused by peripheral neuropathy and limited joint mobility. Despite treatment, ulcers readily b...
590 Citations Source Cite
Published on Jan 1, 2014in Journal of The American Academy of Dermatology 6.90
Afsaneh Alavi13
Estimated H-index: 13
(University of Toronto),
R. Gary Sibbald28
Estimated H-index: 28
(University of Toronto)
+ 7 AuthorsRobert S. Kirsner53
Estimated H-index: 53
(University of Miami)
Diabetes mellitus is a serious, life-long condition that is the sixth leading cause of death in North America. Dermatologists frequently encounter patients with diabetes mellitus. Up to 25% of patients with diabetes mellitus will develop diabetic foot ulcers. Foot ulcer patients have an increased risk of amputation and increased mortality rate. The high-risk diabetic foot can be identified with a simplified screening, and subsequent foot ulcers can be pr...
70 Citations Source Cite
Published on Jan 1, 2016in Diabetes-metabolism Research and Reviews 3.90
Konstantinos Markakis1
Estimated H-index: 1
(Manchester Royal Infirmary),
Frank L. Bowling16
Estimated H-index: 16
(University of Manchester),
Andrew J.M. Boulton84
Estimated H-index: 84
(University of Manchester)
Abstract In 2015, it can be said that the diabetic foot is no longer the Cinderella of diabetic complications. Thirty years ago there was little evidence-based research taking place on the diabetic foot, and there were no international meetings addressing this topic. Since then, the biennial Malvern Diabetic Foot meetings started in 1986, the American Diabetes Association founded their Foot Council in 1987, and the European Association for ...
25 Citations Source Cite
Eoghan McCarthy3
Estimated H-index: 3
(Thomas Jefferson University),
William B. Morrison45
Estimated H-index: 45
(Thomas Jefferson University),
Adam C. Zoga23
Estimated H-index: 23
(Thomas Jefferson University)
Diabetes affects approximately 15 million persons Vascular disease in diabetic patients in the United States alone [1]. In the foot and ankle, diabetes leads to vascular disease [2,3], arthritic disease (typically neuropathic) [4,5], and an increased frequency of tendon disorders [6] and, perhaps most importantly, soft tissue and osseous infection [7,8]. Approximately one-fifth of diabetic patients warrant hospitalization for pedal infections [9]. Historically, amputation ha...
71 Citations Source Cite
Published on Jan 1, 2014in Journal of The American Academy of Dermatology 6.90
Afsaneh Alavi13
Estimated H-index: 13
(University of Toronto),
R. Gary Sibbald28
Estimated H-index: 28
(University of Toronto)
+ 7 AuthorsRobert S. Kirsner53
Estimated H-index: 53
(University of Miami)
The management of diabetic foot ulcers can be optimized by using an interdisciplinary team approach addressing the correctable risk factors (ie, poor vascular supply, infection control and treatment, and plantar pressure redistribution) along with optimizing local wound care. Dermatologists can initiate diabetic foot care. The first step is recognizing that a loss of skin integrity (ie, a callus, blister, or ulcer) considerably increases the risk of preventable amputa...
34 Citations Source Cite
Published on Nov 1, 2016in Diabetic Medicine 3.13
J. W. Walsh1
Estimated H-index: 1
(University of Pennsylvania),
Ole Hoffstad27
Estimated H-index: 27
(University of Pennsylvania)
+ 1 AuthorsDavid J. Margolis77
Estimated H-index: 77
(University of Pennsylvania)
Aims The presence of diabetic foot ulcers is strongly associated with an increased risk of death. In this study, we investigate whether the effects of diabetes-associated complications can explain the apparent relationship between diabetic foot ulcers and death. Methods We analysed data from 414 523 people with diabetes enrolled in practices associated with The Health Improvement Network in the United Kingdom. Our methods were designed to control for potential confoun...
41 Citations Source Cite
S. A. Van Asten2
Estimated H-index: 2
(University of Texas Southwestern Medical Center),
J. La Fontaine1
Estimated H-index: 1
(University of Texas Southwestern Medical Center)
+ 3 AuthorsLawrence A. Lavery65
Estimated H-index: 65
(University of Texas Southwestern Medical Center)
The purpose of this investigation was to evaluate the diversity of bacteria in diabetic foot osteomyelitis using a 16S rRNA sequencing approach and to compare the results with conventional culture techniques. In this prospective observational study, we obtained 34 bone samples from patients admitted to our hospital with a moderate–severe diabetic foot infection. We analysed the distribution of the 16S rRNA gene sequences in the bone samples, using an Illumina MiSeq Pe...
20 Citations Source Cite
Published on May 1, 2015in Diabetes Care 13.40
Kristy Pickwell5
Estimated H-index: 5
(Maastricht University Medical Centre),
Volkert Siersma28
Estimated H-index: 28
(University of Copenhagen)
+ 16 AuthorsNicolaas C. Schaper39
Estimated H-index: 39
(Maastricht University Medical Centre)
Infection commonly complicates diabetic foot ulcers and is associated with a poor outcome. In a cohort of individuals with an infected diabetic foot ulcer, we aimed to determine independent predictors of lower-extremity amputation and the predictive value for amputation of the International Working Group on the Diabetic Foot (IWGDF) classification system and to develop a risk score for predicting amputation.
41 Citations Source Cite