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Published on Apr 1, 2016in Journal of The American Academy of Dermatology 6.90
Jennifer G. Powers7
Estimated H-index: 7
(Duke University),
Catherine Higham5
Estimated H-index: 5
(Vanderbilt University)
+ 1 AuthorsTania J. Phillips39
Estimated H-index: 39
(Boston University)
In the United States, chronic ulcers—including decubitus, vascular, inflammatory, and rheumatologic subtypes—affect >6 million people, with increasing numbers anticipated in our growing elderly and diabetic populations. These wounds cause significant morbidity and mortality and lead to significant medical costs. Preventative and treatment measures include disease-specific approaches and the use of moisture retentive dressings and adjunctive topical therapies to promote healing. In ...
39 Citations Source Cite
Published on Jan 1, 2017in Journal of Investigative Dermatology 6.45
Michael A. Loesche4
Estimated H-index: 4
(University of Pennsylvania),
Sue E. Gardner17
Estimated H-index: 17
(University of Iowa)
+ 9 AuthorsElizabeth A. Grice31
Estimated H-index: 31
(University of Pennsylvania)
Microbial burden of chronic wounds is believed to play an important role in impaired healing and the development of infection-related complications. However, clinical cultures have little predictive value of wound outcomes, and culture-independent studies have been limited by cross-sectional design and small cohort size. We systematically evaluated the temporal dynamics of the microbiota colonizing diabetic foot ulcers, a common and costly complication of diabetes, and its a...
29 Citations Source Cite
Published on Aug 5, 2016in Frontiers in Physiology 3.39
Laura E. Dickinson8
Estimated H-index: 8
,
Sharon Gerecht35
Estimated H-index: 35
(Johns Hopkins University)
Skin regeneration requires the coordinated integration of concomitant biological and molecular events in the extracellular wound environment during overlapping phases of inflammation, proliferation, and matrix remodeling. This process is highly efficient during normal wound healing. However, chronic wounds fail to progress through the ordered and reparative wound healing process and are unable to heal, requiring long-term treatment at high costs. There are many...
23 Citations Source Cite
Published on Jul 1, 2015in Advances in wound care
Kasturi Ganesh7
Estimated H-index: 7
,
Mithun Sinha7
Estimated H-index: 7
+ 3 AuthorsChandan K. Sen74
Estimated H-index: 74
Significance: Multispecies microbial biofilms may contribute to wound chronicity by derailing the inherent reparative process of the host tissue. In the biofilm form, bacteria are encased within an extracellular polymeric substance and become recalcitrant to antimicrobials and host defenses. For biofilms of relevance to human health, there are two primary contributing factors: the microbial species involved and host response which, in turn, shapes microbial processes over time. Thi...
13 Citations Source Cite
Published on Aug 1, 2015in British Journal of Dermatology 6.13
David Leaper33
Estimated H-index: 33
(University of Huddersfield),
Ojan Assadian30
Estimated H-index: 30
(Medical University of Vienna),
Charles E. Edmiston31
Estimated H-index: 31
(Medical College of Wisconsin)
Summary Infection is the likeliest single cause of delayed healing in healing of chronic open wounds by secondary intention. If neglected it can progress from contamination to colonization and local infection through to systemic infection, sepsis and multiple organ dysfunction syndrome, and it can be life-threatening. Infection in chronic wounds is not as easy to define as in acute wounds, and is complicated by the presence of biofilms. There is, as yet, no dia...
32 Citations Source Cite
Published on Apr 1, 2016in Journal of The American Academy of Dermatology 6.90
Laurel M. Morton5
Estimated H-index: 5
(Chestnut Hill College),
Tania J. Phillips39
Estimated H-index: 39
(Boston University)
Wounds are an excellent example of how the field of dermatology represents a cross-section of many medical disciplines. For instance, wounds may be caused by trauma, vascular insufficiency, and underlying medical conditions, such as diabetes, hypertension, and rheumatologic and inflammatory disease. This continuing medical education article provides an overview of wound healing and the pathophysiology of chronic wounds and reviews the broad differential diagnos...
24 Citations Source Cite
Published on Jul 24, 2014in PLOS Genetics 5.54
Keith H. Turner5
Estimated H-index: 5
(University of Texas at Austin),
Jake Everett5
Estimated H-index: 5
(Texas Tech University Health Sciences Center)
+ 2 AuthorsMarvin Whiteley47
Estimated H-index: 47
(University of Texas at Austin)
Opportunistic infections caused by Pseudomonas aeruginosa can be acute or chronic. While acute infections often spread rapidly and can cause tissue damage and sepsis with high mortality rates, chronic infections can persist for weeks, months, or years in the face of intensive clinical intervention. Remarkably, this diverse infectious capability is not accompanied by extensive variation in genomic content, suggesting that the genetic capacity to be an acute or a chronic patho...
93 Citations Source Cite
Published on Apr 15, 2010in British Journal of Dermatology 6.13
S. Schreml2
Estimated H-index: 2
,
R.-M. Szeimies21
Estimated H-index: 21
+ 3 AuthorsPhilipp Babilas27
Estimated H-index: 27
Oxygen is a prerequisite for successful wound healing due to the increased demand for reparative processes such as cell proliferation, bacterial defence, angiogenesis and collagen synthesis. Even though the role of oxygen in wound healing is not yet completely understood, many experimental and clinical observations have shown wound healing to be impaired under hypoxia. This article provides an overview on the role of oxygen in wound healing and chronic wound...
196 Citations Source Cite
Published on Mar 1, 2017in Advances in Therapy 3.08
George Han1
Estimated H-index: 1
(Icahn School of Medicine at Mount Sinai),
Roger I. Ceilley22
Estimated H-index: 22
(University of Iowa)
Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can be affected, resulting in chronic, non-healing wounds that subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of resources. The healing of a superficial wound requires many factors to work in concert, ...
53 Citations Source Cite
Published on Jan 1, 2016in Wound Repair and Regeneration 2.95
Randall D. Wolcott22
Estimated H-index: 22
,
John Hanson2
Estimated H-index: 2
+ 5 AuthorsJennifer White3
Estimated H-index: 3
The extent to which microorganisms impair wound healing is an ongoing controversy in the management of chronic wounds. Because the high diversity and extreme variability of the microbiota between individual chronic wounds lead to inconsistent findings in small cohort studies, evaluation of a large number of chronic wounds using identical sequencing and bioinformatics methods is necessary for clinicians to be able to select appropriate empiric ther...
48 Citations Source Cite