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George M. Church133
Estimated H-index: 133
,
Michael B. Elowitz45
Estimated H-index: 45
+ 2 AuthorsRon Weiss62
Estimated H-index: 62
Synthetic biology, despite still being in its infancy, is increasingly providing valuable information for applications in the clinic, the biotechnology industry and in basic molecular research. Both its unique potential and the challenges it presents have brought together the expertise of an eclectic group of scientists, from cell biologists to engineers. In this Viewpoint article, five experts discuss their views on the future of synthetic biology, on its main achievements in basi...
94 Citations Download PDF Cite
2017 in Angewandte ChemieIF: 12.10
Simon Ausländer9
Estimated H-index: 9
(ETH Zurich),
David Ausländer10
Estimated H-index: 10
(ETH Zurich),
Martin Fussenegger56
Estimated H-index: 56
(University of Basel)
Synthetic biology envisages the engineering of man-made living biomachines from standardized components that can perform pre-defined functions in a (self-)controlled manner. Different research strategies and interdisciplinary efforts are pursued to implement engineering principles to biology. The "top-down" strategy exploits nature's incredible diversity of existing, natural parts to construct synthetic compositions of genetic, metabolic or signalling networks with predictable and ...
33 Citations Source Cite
Mélanie Courtot16
Estimated H-index: 16
,
Nick Juty13
Estimated H-index: 13
(European Bioinformatics Institute)
+ 24 AuthorsNicolas Le Novère52
Estimated H-index: 52
(European Bioinformatics Institute)
The use of computational modeling to describe and analyze biological systems is at the heart of systems biology. Model structures, simulation descriptions and numerical results can be encoded in structured formats, but there is an increasing need to provide an additional semantic layer. Semantic information adds meaning to components of structured descriptions to help identify and interpret them unambiguously. Ontologies are one of the tools frequently used for this purpose. We describe h...
147 Citations Download PDF Cite
2014 in Trends in Cell BiologyIF: 18.56
Nikki Traylor-Knowles12
Estimated H-index: 12
(Stanford University),
Stephen R. Palumbi75
Estimated H-index: 75
(Stanford University)
Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate immunity and acclimatization have prompted new developments in conservation. Similar to biomedicine, we urge that future efforts should focus on better frameworks for...
11 Citations Download PDF Cite
2004 in Nature BiotechnologyIF: 35.72
Hans V. Westerhoff78
Estimated H-index: 78
,
Bernhard O. Palsson120
Estimated H-index: 120
(University of California, San Diego)
Abstract Systems analysis has historically been performed in many areas of biology, including ecology, developmental biology and immunology. More recently, the genomics revolution has catapulted molecular biology into the realm of systems biology. In unicellular organisms and well-defined cell lines of higher organisms, systems approaches are making definitive strides toward scientific understanding and biotechnological applications. We argue here that two distinct li...
376 Citations Download PDF Cite
2015 in Trends in Plant ScienceIF: 12.15
Wusheng Liu9
Estimated H-index: 9
(University of Tennessee),
C. Neal Stewart45
Estimated H-index: 45
(University of Tennessee)
Plant synthetic biology is an emerging field that combines engineering principles with plant biology toward the design and production of new devices. This emerging field should play an important role in future agriculture for traditional crop improvement, but also in enabling novel bioproduction in plants. In this review we discuss the design cycles of synthetic biology as well as key engineering principles, genetic parts, and computational tools that can be utilized in plan...
42 Citations Download PDF Cite
2016 in Chemistry & BiologyIF: 5.92
Milka Kostic1
Estimated H-index: 1
,
Craig M. Crews54
Estimated H-index: 54
+ 2 AuthorsHiroaki Suga40
Estimated H-index: 40
Table of Content Wish List“An Atomic Resolution Map of a Working Cell” (Bridget Carragher)“A Universal Method for Compound Target Identification” (James K. Chen)“A Lego Kit of Biosynthetic Modules for Secondary Metabolite Production” (James K. Chen)“Quantitative Sequencing of Carbohydrate Modifications on Proteins” (James K. Chen)“Evolution of Smart Materials” (Jason Chin)“Mars Needs Histones” (Andrea G. Cochran)“Metabolomic Engineering: A Systems Biology Application of Large Scale Chemic...
4 Citations Source Cite
Jens B. Nielsen42
Estimated H-index: 42
(Novo Nordisk Foundation)
Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed: kinetic models and genome-scale metabolic models. The use of different omics technolo...
16 Citations Source Cite
2017 in PLOS BiologyIF: 9.16
Florian Markowetz25
Estimated H-index: 25
(University of Cambridge)
Here, I argue that computational thinking and techniques are so central to the quest of understanding life that today all biology is computational biology. Computational biology brings order into our understanding of life, it makes biological concepts rigorous and testable, and it provides a reference map that holds together individual insights. The next modern synthesis in biology will be driven by mathematical, statistical, and computational methods being absorbed i...
7 Citations Source Cite
2016 in BMC Systems BiologyIF: 2.05
Elizabeth Brunk12
Estimated H-index: 12
(Joint BioEnergy Institute),
Nathan Mih6
Estimated H-index: 6
(University of California, San Diego)
+ 7 AuthorsBernhard O. Palsson120
Estimated H-index: 120
(University of California, San Diego)
Background The success of genome-scale models (GEMs) can be attributed to the high-quality, bottom-up reconstructions of metabolic, protein synthesis, and transcriptional regulatory networks on an organism-specific basis. Such reconstructions are biochemically, genetically, and genomically structured knowledge bases that can be converted into a mathematical format to enable a myriad of computational biological studies. In recent years, genome-scale reconstructions have been extended to include p...
22 Citations Source Cite