Hispidin and related herbal compounds from <i>Alpinia zerumbet </i>inhibit both PAK1-dependent melanogenesis in melanocytes and reactive oxygen species (ROS) production in adipocytes
Abstract
Recently several compounds from Okinawa plants including Alpinia zerumbet (alpinia) were shown to inhibit directly the oncogenic/ageing kinase PAK1 (p21-activated kinase 1). Furthermore, it was recently revealed that both PAK1 and PAK4 (p21-activated kinase 4) are equally essential for the melanogenesis in melanoma cells. Thus, in this study, we tested if several alpinia compounds inhibit the melanogenesis in melanoma (B16F10) cells, as well as...
Paper Details
Title
Hispidin and related herbal compounds from <i>Alpinia zerumbet </i>inhibit both PAK1-dependent melanogenesis in melanocytes and reactive oxygen species (ROS) production in adipocytes
Published Date
Jan 1, 2015
Volume
9
Issue
3
Pages
197 - 204
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