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IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance

Published on Oct 1, 2015in Cytokine3.08
· DOI :10.1016/j.cyto.2015.05.005
Dov B. Ballak4
Estimated H-index: 4
(Radboud University Nijmegen),
Rinke Stienstra29
Estimated H-index: 29
(Radboud University Nijmegen)
+ 2 AuthorsJ.A. van Diepen2
Estimated H-index: 2
(Radboud University Nijmegen)
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Abstract
Obesity is characterized by a chronic, low-grade inflammation that contributes to the development of insulin resistance and type 2 diabetes. Cytokines and chemokines produced by immunocompetent cells influence local as well as systemic inflammation and are therefore critical contributors to the pathogenesis of type 2 diabetes. Hence, cytokines that modulate inflammatory responses are emerging as potential targets for intervention and treatment of the metabolic consequences of obesity. The interleukin-1 (IL-1) family of cytokines and receptors are key mediators of innate inflammatory responses and exhibit both pro- and anti-inflammatory functions. During the last decades, mechanistic insights into how the IL-1 family affects the initiation and progression of obesity-induced insulin resistance have increased significantly. Here, we review the current knowledge and understanding, with emphasis on the therapeutic potential of individual members of the IL-1 family of cytokines for improving insulin sensitivity in patients with diabetes.
  • References (174)
  • Citations (48)
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References174
Newest
#1Min-Woo Lee (UCSF: University of California, San Francisco)H-Index: 2
#2Justin I. Odegaard (UCSF: University of California, San Francisco)H-Index: 26
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#1Christian Herder (HHU: University of Düsseldorf)H-Index: 62
#2Marja Liisa Nuotio (National Institute for Health and Welfare)H-Index: 6
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#1Yifu Qiu (UCSF: University of California, San Francisco)H-Index: 12
#2Khoa D. Nguyen (UCSF: University of California, San Francisco)H-Index: 21
Last.Ajay Chawla (UCSF: University of California, San Francisco)H-Index: 37
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#1Graham A. Tynan (Trinity College, Dublin)H-Index: 8
#2Claire H. Hearnden (Trinity College, Dublin)H-Index: 5
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#2David Hui (University of Texas MD Anderson Cancer Center)H-Index: 66
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#1Ramu Adela (Translational Health Science and Technology Institute)H-Index: 5
Last.Sanjay K. Banerjee (Translational Health Science and Technology Institute)H-Index: 27
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#1Jessica L. Hill (CSU: Colorado State University)
#2Matia B. Solomon (UC: University of Cincinnati)H-Index: 23
Last.Michelle T. Foster (CSU: Colorado State University)H-Index: 10
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#1Qin Zhang (CAS: Chinese Academy of Sciences)H-Index: 2
#2Ying Pan (CAS: Chinese Academy of Sciences)H-Index: 2
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