Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
Abstract
The primary antibody repertoire is generated by mechanisms involving the assembly of the exons that encode the antigen-binding variable regions of immunoglobulin heavy (IgH) and light (IgL) chains during the early development of B lymphocytes. After antigen-dependent activation, mature B lymphocytes can further alter their IgH and IgL variable region exons by the process of somatic hypermutation (SHM), which allows the selection of B cells in...
Paper Details
Title
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
Published Date
Feb 27, 2015
Journal
Volume
3
Issue
1
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