Separation and Detection of Protein Charge Isoforms with a Combination of OFFGEL- and Labon-Chip Electrophoresis and Mass Spectrometry
Abstract
Separation and analysis of charge heterogeneity in recombinant protein or monoclonal antibody (mAb) production is a prime quality control step in the biopharmaceutical industry. This step is often carried out by a combination of separation techniques followed by mass spectrometric detection. Two dimensional gel electrophoresis (2D-GE) is unrivalled in terms of resolution but is a tedious procedure. Here we present a combination of two easy...
Paper Details
Title
Separation and Detection of Protein Charge Isoforms with a Combination of OFFGEL- and Labon-Chip Electrophoresis and Mass Spectrometry
Published Date
Oct 1, 2011
Volume
22
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