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In vitro antiproliferative effects, toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of five organotin compounds.

Published on Jan 1, 1995in in Vivo1.61
Marcel Gielen34
Estimated H-index: 34
,
Rudolph Willem38
Estimated H-index: 38
+ 4 AuthorsGodefridus J. Peters63
Estimated H-index: 63
Abstract
The in vitro antiproliferative effects, the toxicity profiles in vivo in mice and the antitumour activity in tumour-bearing mice were screened for five recently synthesized organotin compounds: triphenyltin 5-sulfosalicylate (1), triphenyltin 5-aminosalicylate (2), triphenyltin 4-fluorobenzoate (3), tri-n-butyltin 2,6-difluorobenzoate (4) and di-n-butyltin bis (2,5-dihydroxybenzoate) (5). The in vitro chemosensitivity tests showed that compound 1 has the lowest antiproliferative effect in C26-10. In WiDr, compounds 1 and 5 were less active than the other compounds tested. The IC50 for cisplatin in C26-10 was in the same range as for 1. For compound 3 a steep dose response curve in C26-10 turned out to be remarkably different from the curves of the other compounds. In vivo, compound 1 was most toxic, mainly through paralysis. At their maximum tolerated dose (MTD) for single administration compounds 1, 2, 3 and 4 are inactive against murine colon carcinoma Colon 26. At a single administration, compound 5 was the most active compound with Test/Control ratio (T/C) below 0.6 and Growth Delay Factor (GDF) above 1.0, their respective cut-off levels for sensitivity.
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#2Małgorzata Latocha (Medical University of Silesia)H-Index: 12
Last.Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 18
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#1Biplob Koch (NEHU: North Eastern Hill University)H-Index: 17
#2Tushar S. Basu Baul (NEHU: North Eastern Hill University)H-Index: 23
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#1Biplob Koch (NEHU: North Eastern Hill University)H-Index: 17
#2Tushar S. Basu Baul (NEHU: North Eastern Hill University)H-Index: 23
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#1Girish Barot (FAU: Florida Atlantic University)H-Index: 11
#2Kimberly Shahi (UTA: University of Texas at Arlington)H-Index: 10
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#1Marcel Gielen (Vrije Universiteit Brussel)H-Index: 34
#2Monique Biesemans (Vrije Universiteit Brussel)H-Index: 34
Last.Rudolph Willem (Vrije Universiteit Brussel)H-Index: 38
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