Synthesis of Organotin Polyamine Ethers Containing Thiamine (Vitamin B1) and Preliminary Ability to Inhibit Select Cancer Cell Lines

Organotin polyamine ethers containing thiamine (Vitamin B1) were synthesized employing the interfacial polymerization of thiamine and organotin dichlorides. Reaction is rapid occurring in less than 15 s in moderate to poor yield with chain length ranging from 86 to 860 units. Infrared spectroscopy shows new bands characteristic of the formation of the Sn–N and Sn–O linkages. Proton NMR shows the presence of both the organotin and thiamine...