Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

Volume: 94, Issue: 2, Pages: 155 - 171
Published: Feb 1, 2016
Abstract
Since Otto Warburg reported the ‘addiction’ of cancer cells to fermentative glycolysis, a metabolic pathway that provides energy and building blocks, thousands of studies have shed new light on the molecular mechanisms contributing to altered cancer metabolism. Hypoxia, through hypoxia-inducible factors (HIFs), in addition to oncogenes activation and loss of tumour suppressors constitute major regulators of not only the “Warburg effect” but also...
Paper Details
Title
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
Published Date
Feb 1, 2016
Volume
94
Issue
2
Pages
155 - 171
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