Gene Targeting to the Uteroplacental Circulation of Pregnant Guinea Pigs
Abstract
Our study aimed to target adenoviral gene therapy to the uteroplacental circulation of pregnant guinea pigs in order to develop a novel therapy for fetal growth restriction. Four methods of delivery of an adenovirus encoding β-galactosidase (Ad.LacZ) were evaluated: intravascular injection using phosphate-buffered saline (PBS) into (1) uterine artery (UtA) or (2) internal iliac artery or external administration in (3) PBS or (4) pluronic F-127...
Paper Details
Title
Gene Targeting to the Uteroplacental Circulation of Pregnant Guinea Pigs
Published Date
Aug 1, 2016
Journal
Volume
23
Issue
8
Pages
1087 - 1095
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Notes
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