Exposure to Diesel Exhaust Particles Drive Expansion of Cardiac Ischemia‐Reperfusion Injury via Interleukin‐6 Trans‐Signaling in Male Sprague‐Dawley Rats

Exposure to particulate matter has been strongly associated with deleterious impacts on cardiovascular health and function; however, the mechanisms that underlie this association are largely unknown. We have hypothesized that exposure to particulate matter drives cardiovascular expansion of cardiac ischemia‐reperfusion injury (I/R) via a novel mechanism known as IL‐6 trans‐signaling (IL‐6TS) which promotes a proinflammatory state, increasing...