Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis*

To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model and patients with sepsis.Prospective, observational clinical study with in vivo and ex vivo translational laboratory investigations.General ICU and university research laboratory.Sixty-five septic patients and 27 healthy volunteers. Twelve-week-old male C57BL/6N mice.Serial blood samples from 65 patients with sepsis were analyzed, and left...