Of mice and men: The relevance of transgenic mice Aβ immunizations to Alzheimer's disease

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by a time-dependent amyloid fibril deposition in cortical senile plaques and cerebral vascular walls. Several transgenic (Tg) mice have been engineered to overexpress amyloid-beta precursor protein (AβPP) with familial AD mutations. With advancing age, the Tg mice accumulate amyloidbeta (Aβ) peptides, primarily of 40 to 42 amino acids, in plaques and blood vessel...