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Wound fluids: a reflection of the state of healing.
Published on Jan 1, 2000in Ostomy Wound Management 0.99
Staiano-Coico L1
Estimated H-index: 1
,
Higgins Pj1
Estimated H-index: 1
+ 2 AuthorsGoncalves J1
Estimated H-index: 1
Abstract
Analyzing acute and chronic wound fluids provides an important and intriguing insight into the wound milieu. This review outlines some of the salient features of wound repair and the wound fluid environment. Most studies support the premise that the contents of the wound fluid reflect the status of the wound and can be indicative of whether a wound is on the course of a normal or impaired response to injury. For example, chronic wound fluids often differ from acute wound fluids in their proliferative effects on cells active in healing as well as their proteolytic effects. The authors discuss various cytokines, growth factors, proteinases, and protease inhibitors within wound fluids as well as their effect on wound repair. This review also presents confounding factors affecting interpretation of wound fluid studies, suggesting that further studies need to elucidate mechanisms whereby wound fluids either enhance or inhibit wound repair. So far, wound fluid analysis has yielded tantalizing glimpses of the teeming wound environment. What wound fluid contents tell us about the wound or its clinical care is not yet certain.
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  • Cited By (23)
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Cited By23
Published on May 18, 2015
This thesis is concerned with the nature of biomaterial interactions with compromised host tissue sites. Both ocular and dermal tissues can be wounded, following injury, disease or surgery, and consequently require the use of a biomaterial. Clear analogies exist between the cornea/tear film/contact lens and the dermal wound bed/wound fluid/skin adhesive wound dressing. The work described in this thesis builds upon established biochemistry to examine specific aspects of the interaction of biomate...
Published on Dec 7, 2007in British Journal of Dermatology 6.13
Melissa Laura Fernandez4
Estimated H-index: 4
(Queensland University of Technology),
James A. Broadbent7
Estimated H-index: 7
(Queensland University of Technology)
+ 2 AuthorsZee Upton30
Estimated H-index: 30
(Queensland University of Technology)
Summary Background Chronic venous leg ulcers are a significant cause of pain, immobility and decreased quality of life for patients with these wounds. In view of this, research efforts are focused on multiple factors in the wound environment to obtain information regarding the healing of ulcers. Objectives Chronic wound fluid (CWF), containing a complex mixture of proteins, is an important modulator of the wound environment, and therefore we hypothesized that these proteins may be indicators of ...
34 Citations Source Cite
Published on Jan 1, 2013
Ernest Anthony Azzopardi1
Estimated H-index: 1
Abstract Multidrug-resistant Gram-negative infection is an important cause of mortality and morbidity. Management of these infections is often dependent upon “treatment of last resort” "small molecule" antibiotics which suffer from significant toxicity and an indiscriminate volume of distribution. The aim of this study was to develop a prototype polymer-antibiotic conjugate that may be customised by polymer modification and binding chemistry to afford selective, controlled release at an infected...
5 Citations
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Heiko Schuster12
Estimated H-index: 12
(University of Tübingen)
+ 1 AuthorsStefan Beckert16
Estimated H-index: 16
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Feb 1, 2010in Proteomics Clinical Applications 3.57
James A. Broadbent7
Estimated H-index: 7
(Queensland University of Technology),
Terry Walsh8
Estimated H-index: 8
(Queensland University of Technology),
Zee Upton30
Estimated H-index: 30
(Queensland University of Technology)
Chronic wounds, such as venous and diabetic leg ulcers, represent a significant health and financial burden to individuals and healthcare systems. In worst-case scenarios this condition may require the amputation of an affected limb, with significant impact on patient quality of life and health. Presently, there are no clinical biochemical analyses used in the diagnosis and management of this condition; moreover few biochemical therapies are accessible to patients. This presents a significant ch...
21 Citations Source Cite
Published on Jul 1, 2015in Journal of Spinal Cord Medicine 1.88
Laura E. Edsberg13
Estimated H-index: 13
(Daemen College),
Jennifer T. Wyffels8
Estimated H-index: 8
(Daemen College)
+ 2 AuthorsPamela Houghton4
Estimated H-index: 4
(University of Western Ontario)
AbstractObjectiveTo determine whether the biochemistry of chronic pressure ulcers differs between patients with and without chronic spinal cord injury (SCI) through measurement and comparison of the concentration of wound fluid inflammatory mediators, growth factors, cytokines, acute phase proteins, and proteases.DesignSurvey.SettingTertiary spinal cord rehabilitation center and skilled nursing facilities.ParticipantsTwenty-nine subjects with SCI and nine subjects without SCI (>18 years) with at...
4 Citations Source Cite
Published on Apr 1, 2001in Experimental Cell Research 3.31
Dacheng He1
Estimated H-index: 1
(Beijing Normal University),
Ward Casscells3
Estimated H-index: 3
(University of Texas at Austin),
David A. Engler3
Estimated H-index: 3
(University of Texas at Austin)
Abstract We and others have previously shown that basic fibroblast growth factor (FGF-2 or bFGF) can be used as a targeting molecule to help carry plasmid DNA into cells when the growth factor molecule is physically coupled to the DNA molecule being delivered. Herein we report our observations on the FGF-mediated uptake of exogenous labeled DNA into cultured cells in a manner that is representative of that which may occur under physiological conditions at sites of wounded tissue. Cellular debris...
6 Citations Source Cite
Published on Apr 1, 2002in Journal of Surgical Research 2.05
John Goncalves2
Estimated H-index: 2
(Cornell University),
Nabil Wasif4
Estimated H-index: 4
(Cornell University)
+ 5 AuthorsLisa Staiano-Coico23
Estimated H-index: 23
(Cornell University)
Abstract The nitrate form of the Group III transitional element gallium (GN) increases expression of specific structural components of the provisional wound matrix (i.e., collagen type I, fibronectin) in human dermal fibroblasts. To evaluate the potential of GN as a therapeutic option in management of cutaneous trauma, GN-treated partial thickness porcine wounds and experimentally “injured” human keratinocyte (NHK) monolayer cultures were compared with mirror image control (i.e., saline-treated)...
9 Citations Source Cite
Published on Dec 1, 2008in International Wound Journal 2.38
Yunita Sari6
Estimated H-index: 6
(University of Tokyo),
Gojiro Nakagami18
Estimated H-index: 18
(University of Tokyo)
+ 5 AuthorsJunko Sugama22
Estimated H-index: 22
(Kanazawa University)
Deep tissue injury (DTI) is difficult to detect in the early phase. Creatine phosphokinase (CPK) as a muscle enzyme could represent a promising indicator of DTI. However, serum CPK levels reflect the systemic condition rather than the local wound environment. Wound exudates can be indicative of the local wound environment. This study aimed to investigate the usefulness of CPK levels in wound exudates as an indicator of DTI. Rats were divided into control, 6 hours 10-kg and 6 hours 20-kg loading ...
16 Citations Source Cite
Published on Jun 1, 2003in Journal of Investigative Dermatology 6.45
Anna M. Szpaderska9
Estimated H-index: 9
(Loyola University Medical Center),
Eric I. Egozi2
Estimated H-index: 2
(Loyola University Medical Center)
+ 1 AuthorsLuisa A. DiPietro41
Estimated H-index: 41
(Loyola University Medical Center)
The immediate appearance of platelets in wounds and the ability of platelets to release growth factors suggest that platelets are an important trigger of the tissue repair process. To examine the effect of systemic thrombocytopenia on both the inflammatory and proliferative aspects of wound healing, adult mice were rendered thrombocytopenic by intraperitoneal administration of a rabbit antimouse platelet serum. Full-thickness excisional dermal wounds were prepared and analyzed for inflammatory c...
81 Citations Source Cite
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