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Wound fluids: a reflection of the state of healing.

Published on Jan 1, 2000in Ostomy Wound Management 0.99
Lisa Staiano-Coico26
Estimated H-index: 26
Paul J. Higgins34
Estimated H-index: 34
+ 2 AuthorsJohn Goncalves3
Estimated H-index: 3
Analyzing acute and chronic wound fluids provides an important and intriguing insight into the wound milieu. This review outlines some of the salient features of wound repair and the wound fluid environment. Most studies support the premise that the contents of the wound fluid reflect the status of the wound and can be indicative of whether a wound is on the course of a normal or impaired response to injury. For example, chronic wound fluids often differ from acute wound fluids in their proliferative effects on cells active in healing as well as their proteolytic effects. The authors discuss various cytokines, growth factors, proteinases, and protease inhibitors within wound fluids as well as their effect on wound repair. This review also presents confounding factors affecting interpretation of wound fluid studies, suggesting that further studies need to elucidate mechanisms whereby wound fluids either enhance or inhibit wound repair. So far, wound fluid analysis has yielded tantalizing glimpses of the teeming wound environment. What wound fluid contents tell us about the wound or its clinical care is not yet certain.
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  • Citations (23)
Cited By23
Published on Oct 1, 2016in International Wound Journal 2.38
Sarah Ramsay3
Estimated H-index: 3
(Smith & Nephew),
Linda Cowan6
Estimated H-index: 6
+ 2 AuthorsGregory S. Schultz61
Estimated H-index: 61
(University of Florida)
Chronic wounds, including diabetic foot ulcers, pressure ulcers and venous leg ulcers, impact the lives of millions of people worldwide. These types of wounds represent a significant physical, social and financial burden to both patients and health care systems. Wound care has made great progress in recent years as a result of the critical research performed in academic, clinical and industrial settings. However, there has been relatively little translation of basic research discoveries into nov...
6 Citations Source Cite
Published on Jul 1, 2015in Journal of Spinal Cord Medicine 1.88
Laura E. Edsberg13
Estimated H-index: 13
(Daemen College),
Jennifer T. Wyffels8
Estimated H-index: 8
(Daemen College)
+ 2 AuthorsPamela Houghton5
Estimated H-index: 5
(University of Western Ontario)
AbstractObjectiveTo determine whether the biochemistry of chronic pressure ulcers differs between patients with and without chronic spinal cord injury (SCI) through measurement and comparison of the concentration of wound fluid inflammatory mediators, growth factors, cytokines, acute phase proteins, and proteases.DesignSurvey.SettingTertiary spinal cord rehabilitation center and skilled nursing facilities.ParticipantsTwenty-nine subjects with SCI and nine subjects without SCI (>18 years) with at...
4 Citations Source Cite
Published on May 18, 2015
This thesis is concerned with the nature of biomaterial interactions with compromised host tissue sites. Both ocular and dermal tissues can be wounded, following injury, disease or surgery, and consequently require the use of a biomaterial. Clear analogies exist between the cornea/tear film/contact lens and the dermal wound bed/wound fluid/skin adhesive wound dressing. The work described in this thesis builds upon established biochemistry to examine specific aspects of the interaction of biomate...
Published on Aug 1, 2014in Tissue Engineering and Regenerative Medicine 1.22
Eunkyung Chung6
Estimated H-index: 6
(Kyung Hee University),
Woosung Ahn5
Estimated H-index: 5
(Kyung Hee University),
Youngsook Son19
Estimated H-index: 19
(Kyung Hee University)
We previously reported that wound fluid generated from injured cornea at 5 day after injury had ability to induce mesenchymal to epithelial transition (MET) of circulating mesenchymal stem cells (MSCs). In the present study, we further analyzed wound fluid by cytokine array. Comparing with normal cornea, increased expression of chemokines CXCL2, CXCL3, CXCL5, CCL2, anti-inflammatory cytokine IL-10, growth factors VEGF and β-NGF, protease inhibitor TIMP-1 were observed in the wound fluid of injur...
3 Citations Source Cite
Published on Jul 1, 2014in Expert Review of Molecular Diagnostics 3.33
Ferdinando Mannello30
Estimated H-index: 30
Daniela Ligi10
Estimated H-index: 10
+ 1 AuthorsJoseph D. Raffetto28
Estimated H-index: 28
(Brigham and Women's Hospital)
Chronic venous disease represents a healthcare problem due to high prevalence and recurrence rates. Studies on chronic venous ulcer wound fluid (CVUWF) have demonstrated increased inflammation and proteolysis which can cause tissue destruction and delayed healing. This review discusses: nearly all known metabolites discovered in the past 25 years in CVUWF studies; the omics approaches characterizing the microenvironment of human venous leg ulcers; and the use of biocompounds as prognostic biomar...
16 Citations Source Cite
Markus Loeffler77
Estimated H-index: 77
(University of Tübingen),
Heiko Schuster13
Estimated H-index: 13
(University of Tübingen)
+ 1 AuthorsStefan Beckert17
Estimated H-index: 17
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Jan 1, 2013
Ernest Anthony Azzopardi1
Estimated H-index: 1
Abstract Multidrug-resistant Gram-negative infection is an important cause of mortality and morbidity. Management of these infections is often dependent upon “treatment of last resort” "small molecule" antibiotics which suffer from significant toxicity and an indiscriminate volume of distribution. The aim of this study was to develop a prototype polymer-antibiotic conjugate that may be customised by polymer modification and binding chemistry to afford selective, controlled release at an infected...
5 Citations
Published on Oct 1, 2010in Nutrition in Clinical Practice 2.59
Charles E. Wade71
Estimated H-index: 71
Steven E. Wolf62
Estimated H-index: 62
+ 8 AuthorsKevin K. Chung28
Estimated H-index: 28
Background: A relatively new technology in wound care, negative pressure wound therapy (NPWT), has become widely used for the management of open abdomens and soft tissue wounds and provides a means to collect wound exudate to quantify protein loss. Methods: A prospective observational study was conducted in surgical, trauma, or burn patients (8 patients with open abdomens and 9 patients with acute soft tissue wounds on NPWT). NPWT exudate was collected and assayed to characterize loss of protein...
38 Citations Source Cite
Published on Feb 1, 2010in Proteomics Clinical Applications 3.57
James A. Broadbent7
Estimated H-index: 7
(Queensland University of Technology),
Terence Patrick Walsh17
Estimated H-index: 17
(Queensland University of Technology),
Zee Upton31
Estimated H-index: 31
(Queensland University of Technology)
Chronic wounds, such as venous and diabetic leg ulcers, represent a significant health and financial burden to individuals and healthcare systems. In worst-case scenarios this condition may require the amputation of an affected limb, with significant impact on patient quality of life and health. Presently, there are no clinical biochemical analyses used in the diagnosis and management of this condition; moreover few biochemical therapies are accessible to patients. This presents a significant ch...
21 Citations Source Cite
Published on Sep 1, 2009in The FASEB Journal 5.59
Heiko Sorg12
Estimated H-index: 12
Christian Krueger4
Estimated H-index: 4
+ 3 AuthorsBrigitteVollmar55
Estimated H-index: 55
The hematopoietic growth factor erythropoietin (EPO) attracts attention due to its all-tissue-protective pleiotropic properties. We studied the effect of EPO on dermal regeneration using intravital microscopy in a model of full dermal thickness wounds in the skin-fold chamber of hairless mice. Animals received repetitive low doses or high doses of EPO (RLD-EPO or RHD-EPO) or a single high dose of EPO (SHD-EPO). SHD-EPO accelerated wound epithelialization, reduced wound cellularity, and induced m...
50 Citations Source Cite