Anchor-based classification and type-C inhibitors for tyrosine kinases

Volume: 5, Issue: 1
Published: Jun 16, 2015
Abstract
Tyrosine kinases regulate various biological processes and are drug targets for cancers. At present, the design of selective and anti-resistant inhibitors of kinases is an emergent task. Here, we inferred specific site-moiety maps containing two specific anchors to uncover a new binding pocket in the C-terminal hinge region by docking 4,680 kinase inhibitors into 51 protein kinases, and this finding provides an opportunity for the development of...
Paper Details
Title
Anchor-based classification and type-C inhibitors for tyrosine kinases
Published Date
Jun 16, 2015
Volume
5
Issue
1
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