High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density

Volume: 191, Issue: 1, Pages: 49 - 58
Published: Jul 1, 2015
Abstract
We describe a high throughput method for screening up to 1728 distinct chemicals with protein crystals on a single microplate. Acoustic droplet ejection (ADE) was used to co-position 2.5nL of protein, precipitant, and chemicals on a MiTeGen in situ-1 crystallization plate™ for screening by co-crystallization or soaking. ADE-transferred droplets follow a precise trajectory which allows all components to be transferred through small apertures in...
Paper Details
Title
High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density
Published Date
Jul 1, 2015
Volume
191
Issue
1
Pages
49 - 58
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