Promethazine as a Novel Prophylaxis and Treatment for Nerve Agent Poisoning

: The present study evaluated promethazine, an FDA-approved antihistamine, for treating the toxic effects of soman (GD). Male Sprague-Dawley rats, weighing 240-300 g, were pretreated 30 minutes prior to or treated less than or equal 1 minute after GD administration (180 mg/kg, sc) with promethazine alone (40 mg/kg, ip) or in combination with oxime reactivator HI-6 (125 mg/kg, ip) and atropine methylnitrate (AMN; 2.0 mg/kg, im). The incidence of...