The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment

Introduction It is unclear whether white matter hyperintensities (WMHs), magnetic resonance imaging markers of small‐vessel cerebrovascular disease, promote neurodegeneration and associated clinical decline in Alzheimer's disease (AD), or simply co‐occur with recognized pathogenic processes. Methods In 169 patients with mild cognitive impairment, followed for 3 years, we examined the association of (1) baseline regional WMH and cerebral spinal...