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Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12

Published on Oct 1, 2015in Carbohydrate Polymers6.04
· DOI :10.1016/j.carbpol.2015.06.016
Liqin Wang5
Estimated H-index: 5
(SDAU: Shandong Agricultural University),
Nuo Xu10
Estimated H-index: 10
(SDAU: Shandong Agricultural University)
+ 4 AuthorsLe Jia18
Estimated H-index: 18
(SDAU: Shandong Agricultural University)
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Abstract
Abstract Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest. The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C. militaris SU-12, and to investigate the pharmacological effects of RPS on lipid metabolism and oxidative stress. RPS was composed of glucose, arabinose and mannose with a ratio of 62:1.6:1 by gas chromatography analysis, and the Mw (weight-average molecular weight), Mn (number-average molecular weight) and Mz ( z -average molecular weight) of RPS were 2.86 × 10 3 , 6.85 × 10 2 , and 1.97 × 10 4  Da, respectively. The mice experiments demonstrated that RPS could reduce the levels of blood and liver lipid, and improve the glutamate pyruvate transaminase and antioxidant activity. The histopathological observations of mice livers indicated that RPS could attenuate liver cell injury. Results suggest that the RPS might be used as a potential antihyperlipidemic, hepatoprotective and antioxidant product.
  • References (32)
  • Citations (39)
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References32
Newest
Published on Oct 1, 2013in Carbohydrate Polymers6.04
Tao Qiu3
Estimated H-index: 3
(Hefei University of Technology),
Xiaojing Ma2
Estimated H-index: 2
(Hefei University of Technology)
+ 2 AuthorsYanna Wu4
Estimated H-index: 4
(Hefei University of Technology)
Abstract The extracellular polysaccharide (LEP) produced by Lachnum YM281 was obtained from the fermentation broth, and LEP-1b with molecular weight of 4.02 × 10 4 Da was separated and sequentially purified through DEAE-cellulose 52 column chromatography and Sepharose CL-6B column chromatography. GC–MS, IR and NMR ( 1 H, 13 C) spectroscopy analysis indicated that the repeat unit of LEP-1b was: Download full-size image The effects of LEP-1b on the serum lipids, liver lipids levels and aminotransf...
Published on Oct 1, 2013in International Journal of Biological Macromolecules4.78
Li Wang22
Estimated H-index: 22
(Jiangnan University),
Ying Zhang2
Estimated H-index: 2
+ 6 AuthorsXiguang Qi10
Estimated H-index: 10
(Jiangnan University)
Abstract Vaccinium bracteatum Thunb. (VBT) is a traditional Chinese herbal medicine. The anti-diabetic activity of VBT leaves’ polysaccharide (VBTLP) is studied in this paper. The results indicated VBTLP had a dose-dependent decrease on the blood glucose (BG) level, and the time effect of VBTLP on BG level was also significant. The insulin level of high dose group (HDG) was significantly higher ( p p p
Published on Oct 1, 2013in Carbohydrate Polymers6.04
Jing Zhu4
Estimated H-index: 4
(CPU: China Pharmaceutical University),
Wenying Liu14
Estimated H-index: 14
(CPU: China Pharmaceutical University)
+ 4 AuthorsXiangdong Gao20
Estimated H-index: 20
(CPU: China Pharmaceutical University)
Abstract Diabetes mellitus is a group of complicated metabolic disorders characterized by high blood glucose level and inappropriate insulin secreting capacity due to decreased glucose metabolism and pancreatic β cell mass or dysfunction of β cells. Thus, improving glucose metabolism and preserving β cell mass and function might be useful for the treatment of diabetes. In this study, a novel acidic polysaccharide LBP-s-1 extracted from Lycium barbarum L. was obtained by purification using macrop...
Published on Aug 1, 2013in Carbohydrate Polymers6.04
Fhernanda R. Smiderle17
Estimated H-index: 17
(UFPR: Federal University of Paraná),
Guilherme L. Sassaki34
Estimated H-index: 34
(UFPR: Federal University of Paraná)
+ 1 AuthorsMarcello Iacomini38
Estimated H-index: 38
(UFPR: Federal University of Paraná)
Abstract Cordyceps militaris dried fruiting bodies were extracted with 5% KOH solution. The extract was purified by freeze-thawing treatment, and dialysis (100 kDa), giving rise to a homogeneous polysaccharide ( M w 23,000 Da). Its monosaccharide composition was mannose (56.7%), galactose (34.5%), and glucose (8.8%). The anomeric configurations were determined by their coupling constants. A complex polysaccharide was identified by NMR and methylation analysis. The HSQC spectrum showed signals at...
Published on Jun 1, 2013in Journal of Food and Drug Analysis4.18
Yu-Ling Wen1
Estimated H-index: 1
(NCHU: National Chung Hsing University),
Li-Pyng Yan1
Estimated H-index: 1
(THU: Tunghai University),
Chinshuh Chen2
Estimated H-index: 2
(NCHU: National Chung Hsing University)
Abstract The feasibility of using Aspergillus oryzae NCH 42, an extracellular tannase-producing fungus, for increasing the utilization of extraction residues of Chinese herbal medicines (CHMs) was evaluated in this study. Four types of CHMs, including Trichosanthes kirilowii Maxim, Salvia miltiorrhiza Bge, Magnolia officinalis and Glycyrrhizae radix , were used. Their aqueous extraction residues were inoculated with A. oryzae NCH 42, and solid-state fermentation was performed for 5 days at 30 °C...
Published on Jun 1, 2013in Carbohydrate Polymers6.04
Min Zhu1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University),
Ping Nie1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University)
+ 1 AuthorsBing Wang2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
Abstract Process conditions (extraction time, extraction temperature, water/solid ratio and incubation time) of Shiitake mushroom polysaccharides (SMP) were optimized by conducting experiments at three different levels using the response surface method (RSM). A second-order polynomial response surface equation was developed indicating the effect of variables on polysaccharides yield. Contour maps generated using the response surface equation showed that all the experimental variables significant...
Published on Nov 1, 2012in Carbohydrate Polymers6.04
Xin Liu7
Estimated H-index: 7
,
Zhenliang Sun8
Estimated H-index: 8
+ 5 AuthorsChangheng Liu8
Estimated H-index: 8
Abstract Polysaccharides (AJP) were prepared from Apostichopus japonicus by protease hydrolysis method. Antioxidant activity in vitro and antihyperlipidemic activity in vivo was investigated. Chemical composition analysis indicated that AJP was mainly composed of glucosamine, galactosamine, glucuronic acid, mannose, glucose, galactose and fucose, with an average molecular weight of about 36.2 kDa. The antioxidant capacities of AJP were, respectively, evaluated by the assays of scavenging DPPH, h...
Published on Sep 1, 2012in Food Chemistry5.40
Long-Yan Zhao1
Estimated H-index: 1
(HAU: Hunan Agricultural University),
Wei Huang1
Estimated H-index: 1
(HAU: Hunan Agricultural University)
+ 4 AuthorsFuhua Zeng5
Estimated H-index: 5
(ZNU: Zhanjiang Normal University)
Abstract The antihyperlipidaemic effects of ODP-Ia, one of the main components of Opuntia dillenii Haw. polysaccharides, were studied. Gavage administration of ODP-Ia was observed to significantly decrease serum lipid levels and to increase serum high-density lipoprotein cholesterol level in hyperlipidaemic rats. Similar suppressive patterns were also seen in hepatic total cholesterol and triglyceride levels. Moreover, the ODP-Ia administration significantly increased serum lecithin:cholesterol ...
Published on Dec 1, 2010in Fitoterapia2.43
Shonkor Kumar Das6
Estimated H-index: 6
(University of Fukui),
Mina Masuda9
Estimated H-index: 9
(University of Fukui)
+ 1 AuthorsMikio Sakakibara18
Estimated H-index: 18
(University of Fukui)
Abstract Cordyceps militaris is a potential harbour of bio-metabolites for herbal drugs and evidences are available about its applications for revitalization of various systems of the body from ancient times. Amongst all the species, C. militaris is considered as the oldest source of some useful chemical constituents. Besides their popular applications for tonic medicine by the all stairs of the community, the constituents of C. militaris are now used extensively in modern systems of medicine. T...
Published on Aug 1, 2010in Food Chemistry5.40
Tuoping Li9
Estimated H-index: 9
(Liaoning University),
Suhong Li7
Estimated H-index: 7
(SYNU: Shenyang Normal University)
+ 5 AuthorsHuili Zhang1
Estimated H-index: 1
(Liaoning University)
The anti-hyperlipidemic and antioxidant effects of haw pectic oligosaccharide (HPOS) were investigated using a model of hyperlipidemia induced by a high-fat diet in mice. HPOS significantly lowered the serum levels of total cholesterol (p < 0.01) and triglycerides (p < 0.05) and inhibited the accumulation of body fat in this model. It significantly enhanced the activity of superoxide dismutase to suppress oxidative reactions (p < 0.01) and inhibited the synthesis and accumulation of malondialdeh...
Cited By39
Newest
Published on Oct 1, 2019in Food and Chemical Toxicology3.77
Hongliang Zeng11
Estimated H-index: 11
(Fujian Agriculture and Forestry University),
Peilin Chen1
Estimated H-index: 1
(Fujian Agriculture and Forestry University)
+ 2 AuthorsYi Zhang13
Estimated H-index: 13
(Fujian Agriculture and Forestry University)
Abstract The objective was to investigate the hypolipidemic effect of polysaccharides from Fortunella margarita (Lour.) Swingle (FMPS) in hyperlipidemic rats and the comparative relationship between in vitro and in vivo . After FMPS feeding, the body weight, liver and spleen index of the hyperlipidemic rats decreased significantly, in a dose-dependent manner. The content of triglyceride, total cholesterol, low density lipoprotein and serum non-esterified fatty acid decreased, and high density li...
Published on Aug 1, 2019in International Journal of Biological Macromolecules4.78
Wenshuai Wang3
Estimated H-index: 3
(SDAU: Shandong Agricultural University),
Xinling Song5
Estimated H-index: 5
(SDAU: Shandong Agricultural University)
+ 5 AuthorsLe Jia18
Estimated H-index: 18
(SDAU: Shandong Agricultural University)
Abstract The present work aimed to investigate the antioxidant, hepatic and renal protective effects of water-extractable polysaccharides (WPS) by Dictyophora indusiata fruiting body on high-fat emulsion-induced obese mice. The structural analysis indicated that WPS was the α-configurational heteropolysaccharide with the major monosaccharides of mannose and glucose, and the polydispersity of 1.77. The in vivo results showed that WPS administration could improve obesity-associated hepatic and ren...
Published on Jul 1, 2019in International Journal of Biological Macromolecules4.78
Jixian Zhang5
Estimated H-index: 5
(Jiangsu University),
Chaoting Wen4
Estimated H-index: 4
(Jiangsu University)
+ 2 AuthorsHaile Ma13
Estimated H-index: 13
(Jiangsu University)
Abstract Cordyceps militaris is a unique and precious medical fungus in Chinese Cordyceps, which has been widely used as the traditional medicines or as biocontrol agents against pests in China for centuries. Polysaccharides are one of bioactive constituents in Cordyceps militaris with a variety of biological activities, including immunomodulation, antioxidant, anti-tumor, and anti-aging activities, among others. However, natural Cordyceps militaris are very rare and expensive, most of literatur...
Published on Jun 1, 2019in International Journal of Biological Macromolecules4.78
Xiao-Cui Liu1
Estimated H-index: 1
(Xihua University),
Zhen-Yuan Zhu13
Estimated H-index: 13
(Tianjin University of Science and Technology)
+ 1 AuthorsHui-Qing Sun7
Estimated H-index: 7
(Tianjin University of Science and Technology)
Abstract A comparison of the anti-tumor activity of CMPS-II and CBPS-II polysaccharides, respectively is obtained from the fermented mycelium and cultivated fruiting bodies of Cordyceps militaris . This in vitro anti-tumor activity is investigated using an MTT assay, immunofluorescence staining, a Western Blot assay, a qRT-PCR assay, and Annexin V-FITC/PI double staining. The experimental results indicate that the inhibition rate of CMPS-II on H1299 tumor cells is higher than that of CBPS-II. Wi...
Published on Apr 1, 2019in Journal of Bioscience and Bioengineering2.03
Chien-Chang Wang , Jiun-Yan Wu2
Estimated H-index: 2
(NCHU: National Chung Hsing University)
+ 2 AuthorsYung-Chuan Liu23
Estimated H-index: 23
(NCHU: National Chung Hsing University)
Cordyceps militaris exo-polysaccharides (EPS) have been reported to possess many benefits, such as anti-tumor, anti-inflammatory and antioxidant activities. In this study, the production of EPS via cultivation in a bioreactor was investigated. Glucose and yeast extract were determined to be the most suitable carbon and nitrogen sources for EPS production. The appropriate levels of glucose and yeast extract were 40 g/L and 10 g/L, respectively, resulting in EPS production of 1.686 g/L in a submer...
Published on Mar 1, 2019in International Journal of Biological Macromolecules4.78
Lulu Chu (JXAU: Jiangxi Agricultural University), Licong Yang2
Estimated H-index: 2
(JXAU: Jiangxi Agricultural University)
+ 5 AuthorsGuodong Zheng2
Estimated H-index: 2
(JXAU: Jiangxi Agricultural University)
Abstract The aim of this study is to investigate hypolipidemic and antioxidant effects of Pine needle polysaccharide (PNP) from Pinus massoniana in high-fat diet (HFD)-induced mice. PNP could significantly improve the serum lipid levels (total cholesterol, triacylglycerols, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol), enhance the antioxidant enzymes levels (total antioxidant capability, superoxide dismutase, glutathione peroxidase, catalase), and decrease malondial...
Published on Mar 1, 2019in International Journal of Biological Macromolecules4.78
Yi Ru1
Estimated H-index: 1
(FZU: Fuzhou University),
Xiao Chen1
Estimated H-index: 1
(FZU: Fuzhou University)
+ 4 AuthorsBin Qiu35
Estimated H-index: 35
(FZU: Fuzhou University)
Abstract In this study, a novel polysaccharide TDGP-3 from Tetrastigma hemsleyanum Diels et Gilg was extracted by enzymolysis-ultrasonic assisted extraction (EUAE) method and its antioxidant and hypolipidemic activities were evaluated. With a molecular weight of 3.31 × 10 5 Da, TDGP-3 was composed of 1,4-Glcp, 1,4-Glap and 1,3,6-Manp linkage in the main chain. TDGP-3 showed potential effects on relieving hyperlipidemia and preventing oxidative stress, reflecting by regulating blood lipid levels ...
Published on Feb 1, 2019in International Journal of Biological Macromolecules4.78
Zhanwei Yang4
Estimated H-index: 4
(JXAU: Jiangxi Agricultural University),
Jing Zhao2
Estimated H-index: 2
+ 3 AuthorsWenjun Wang5
Estimated H-index: 5
(JXAU: Jiangxi Agricultural University)
Abstract The present study was conducted to evaluate the effect of CPP on the DNA methylation and expressions of lipid metabolism-related genes (leptin and MTTP) in hyperlipidemic rats. After 8 weeks intervention of CPP, the abdominal wall fat index, liver weight, the serum concentrations of TC, TG and LDL-C were significantly decreased, while HDL was increased. In addition, DNA methylation was analyzed by bisulfite sequencing method, and the mRNA expression levels of leptin and MTTP were detect...
Published on Feb 1, 2019in Journal of Molecular Structure2.12
Qiaoying Song1
Estimated H-index: 1
(Tianjin University of Science and Technology),
Zhen-Yuan Zhu13
Estimated H-index: 13
(Tianjin University of Science and Technology)
+ 2 AuthorsDan-Yang Wang1
Estimated H-index: 1
(Tianjin University of Science and Technology)
Abstract Crude polysaccharide of Cordyceps militaris was obtained by hot water extraction, Sevag deproteinization and alcohol precipitation, and then purified by Sephadex G-200 column chromatography. The extraction purified was named as CPS. The effects of pH, Ca 2+ and DMSO on the structure of the CPS were analyzed by HPLC, Congo red assay, circular dichroism spectra and Atomic force microscopy (AFM) respectively. The results showed that the great changes of the retention time, spatial structur...
Published on Dec 1, 2018in International Journal of Biological Macromolecules4.78
Zhenzhen Ren7
Estimated H-index: 7
(SDAU: Shandong Agricultural University),
Wenbo Liu1
Estimated H-index: 1
(SDAU: Shandong Agricultural University)
+ 5 AuthorsLe Jia18
Estimated H-index: 18
(SDAU: Shandong Agricultural University)
Abstract The present work investigated the antioxidative, anti-inflammatory and organ protective effects of residue polysaccharide (RPS) and its enzymatic-RPS (ERPS) of Lentinula edodes against the LPS-induced sepsis in mice. The results demonstrated that ERPS showed superior effects on inhibiting serum activities of CKMB, LDH, AST, ALP and ALT, lowing the serum levels of BUN, CRE and UA, as well as improving the antioxidant status (SOD, CAT, GSH-P X and T-AOC) than RPS. Moreover, the levels of ...
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