Genetic evidence for the role of muscle-specific acetylcholine receptors in the formation of neuromuscular synapses

Synaptic specialization requires interactions between presynaptic postsynaptic, and glial partners. The development of mouse neuromuscular junctions is pre- patterned within a narrow central band of muscle, where motor axons undergo two aspects of presynaptic differentiation: regulated branching and specialization of nerve terminals. Evidence suggests that acetylcholine (ACh) inhibits nerve branching and presynaptic specialization, yet it is...