Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos
Abstract
Locomotion and respiration require motor axon connectivity and activation of the neuromuscular junction (NMJ). Through a forward genetic screen for muscle weakness, we recently reported an allele of ryanodine receptor type 1 (Ryr1AG). Here we reveal a role for functional RyR1 during acetylcholine receptor (AChR) cluster formation and embryonic synaptic transmission. Ryr1AG homozygous embryos are non-motile. Motor axons extend past AChR clusters...
Paper Details
Title
Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos
Published Date
Aug 1, 2015
Journal
Volume
404
Issue
2
Pages
76 - 87
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