Drug action on anxiety models with special reference to serotonergic mechanisms

Published: Jan 1, 1988
Abstract
A study has been made of drugs acting at 5-HT receptors on animal models of anxiety. An elevated X-maze was used as a model of anxiety for rats and the actions of various ligands for the 5-HT receptor, and its subtypes, were examined in this model. 5-HT agonists, with varying affinities for the 5-HT receptor subtypes, were demonstrated to have anxiogenic-like activity. The 5-HT2 receptor antagonists ritanserin and ketanserin exhibited an...
Paper Details
Title
Drug action on anxiety models with special reference to serotonergic mechanisms
Published Date
Jan 1, 1988
Journal
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