Epigenetic Control of T-Cell Receptor Locus Rearrangements in Normal and Aberrant Conditions

Pages: 295 - 329
Published: Jan 1, 2014
Abstract
V(D)J recombination is the process responsible for the exclusive expression of one antigen receptor form, either T-cell receptor (TCR) or immunoglobulin (Ig), per individual T or B lymphocyte, respectively. This process is, therefore, essential for adaptive immune responses in vertebrates and it consists of the assembly of disperse gene segments present at the TCR and Ig loci to obtain a genetic structure that is able to encode a functional...
Paper Details
Title
Epigenetic Control of T-Cell Receptor Locus Rearrangements in Normal and Aberrant Conditions
Published Date
Jan 1, 2014
Pages
295 - 329
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