The biological chemistry of gold

Published on Dec 1, 1976in Gold Bulletin2.279
· DOI :10.1007/BF03215415
Peter J. Sadler92
Estimated H-index: 92
(Birkbeck, University of London)
Interest in the effects of gold compounds on biological systems ranges from their use for anti-inflammatory and anti-bacterial purposes to the study of the method of uptake of gold by micro-organisms. By the application of modern physical techniques new light is being shed on the mechanism of action of gold in these areas.
  • References (20)
  • Citations (25)
📖 Papers frequently viewed together
1 Author (Peter J. Sadler)
103 Citations
116 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1F.R. SalemmeH-Index: 3
#2S T FreerH-Index: 17
Last. Joseph KrautH-Index: 54
view all 5 authors...
Abstract The structure of ferricytochrome c2 from the non-sulfur purple photosynthetic bacterium Rhodospirillum rubrum has been determined at 2 A resolution by x-ray crystallographic methods. The 112-residue polypeptide chain encloses a single covalently bound heme in a predominantly hydrophobic environment, leaving only one edge exposed to the solvent at the front of the molecule. Distributed around the exterior perimeter of the heme crevice are 11 lysine residues which form an essentially unin...
163 CitationsSource
#1Marc Horisberger (Nestlé)H-Index: 21
#2Jaqueline Rosset (Nestlé)H-Index: 1
Last. Heinz Bauer (Nestlé)H-Index: 12
view all 3 authors...
A rapid method has been developed to visualize cell surface receptors in the SEM. Thus mannan at the surface ofCandida utilis cells was localized by stabilized colloidal gold granules coated with either antimannan antibodies or Con A.
192 CitationsSource
#1T J Constable (University of Birmingham)H-Index: 6
#2A. P. Crockson (University of Birmingham)H-Index: 10
Last. B McConkey (University of Birmingham)H-Index: 14
view all 4 authors...
40 CitationsSource
Abstract A Bence-Jones protein, Rhe, isolated from the urine of a myeloma patient, has been crystallized. Immunological tests indicate that Rhe contains the constant region of a lambda-type light chain. Gel filtration and sodium dodecyl sulfate gel electrophoresis show that Rhe consists of two subunits, each about half the size of the light chain. Preliminary X-ray crystallographic results and density measurements show that Rhe possesses crystallographic 2-fold symmetry, indicating that the two ...
13 CitationsSource
Abstract An electron density map of the oxidized form of flavodoxin from Clostridium strain MP has been calculated to a resolution of 1.9 A employing isomorphous and anomalous scattering data from two heavy atom derivatives, Smiii and Aui. In the region from 3.0 to 1.9 A, the largest structure amplitudes (85% of the total | F | s) have been included in the computation. The over-all figure of merit is 0.808. The molecular model resulting from interpretation of this map has a chain length of 138 r...
182 Citations
Abstract The three-dimensional structure of hemoglobin from the bloodworm, Glycera dibranchiata, has been determined crystallographically to a resolution of 2.5 A using three isomorphous heavy atom derivatives. Approximately 79% of the 147 amino acid residues are in seven helical segments which are disposed in the familiar "myoglobin fold." The heme group is enclosed in a hydrophobic cavity which is formed by the particular folding of the polypeptide chain. The D helix is absent and the position...
120 Citations
#1R. J. Martin (PSU: Pennsylvania State University)H-Index: 18
#2Patricia Lamprey (PSU: Pennsylvania State University)H-Index: 1
Abstract Introduction of hyperphagia by injection of aurothioglucose resulted in rapid deposition of tissue lipid. The changes in tissue enzyme levels and in vivo rates of lipogenesis from U- 14 C glucose were measured at 2, 4, and 8-week intervals post-aurothioglucose injection. Rapid increases of both enzyme activity and in vivo lipogenesis were observed during the onset of obesity. The elevated levels of adipose tissue enzyme activities were restored to normal levels 8 weeks post-injection. H...
11 CitationsSource
20 CitationsSource
#1Georg E. Schulz (MPG: Max Planck Society)H-Index: 55
#2K. Biedermann (MPG: Max Planck Society)H-Index: 1
Last. R. H. Schirmer (MPG: Max Planck Society)H-Index: 9
view all 4 authors...
Abstract A low resolution model of adenylate kinase has been derived from a 6 A electron density map. The molecular shape can be described approximately as an oblate ellipsoid with dimensions 40 A × 40 A × 30 A. The molecule is composed of two globular units separated by a 10 A deep cleft. In contrast to the bigger unit, the smaller globule appears to contain a high amount of α-helical structure. The location of the active centre is discussed. The crystals used for X-ray diffraction analysis bel...
36 CitationsSource
30 CitationsSource
Cited By25
#1Snežana Radisavljević (University of Kragujevac)H-Index: 3
#2Biljana Petrović (University of Kragujevac)H-Index: 15
In the last few years metallodrugs play the key role in the development of medicinal chemistry. The choice of metal ion, its oxidation state, stability, the choice of inert and labile ligands are just some of the very important facts which must be considered before starting the synthesis of complexes with utilization in medicinal purpose. As a result, a lot of compounds of different transition metal ions found application for diagnostic and therapeutic purpose. Beside all, gold compounds have at...
#1Anna Giorgio (University of Naples Federico II)H-Index: 3
#2Antonello Merlino (University of Naples Federico II)H-Index: 29
Abstract Gold compounds have emerged as a novel class of metallodrugs with a promising future in medicinal inorganic chemistry. Despite gold compounds have been intensively investigated for the treatment of many diseases, their mechanism of action is not fully understood at the molecular level. However, the recognition process by proteins is accepted as a key feature for the biological activity of these molecules. This review presents the research performed during the last decade(s) concerning t...
2 CitationsSource
#1Syed G. T. Kazimi (UOS: University of Sargodha)H-Index: 1
#2Mohammad S. Iqbal (Forman Christian College)H-Index: 16
Last. C. Frank Shaw (ISU: Illinois State University)H-Index: 1
view all 3 authors...
Interaction of auricyanide, an important metabolite of anti-arthritic gold-based drug auranofin, was studied in vitro with a pharmacologically active ligand n-acetylcysteine with a view to understand reactivity of gold in vivo. Formation of reduction product aurocyanide occurred through mono- and di-n-acetylcysteine-substituted intermediates. The product and intermediates were identified and monitored spectrophotometrically and by electrospray ionization mass spectrometry. This study suggests su...
#1Karoline Habermann (Goethe University Frankfurt)H-Index: 2
#2Leon Grünewald (Goethe University Frankfurt)H-Index: 1
Last. Simone Fulda (DKFZ: German Cancer Research Center)H-Index: 78
view all 4 authors...
Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death
9 CitationsSource
#1Krishna P. Bhabak (Presidency University, Kolkata)H-Index: 16
#2Debasish Bhowmick (IISc: Indian Institute of Science)H-Index: 6
In the present study we describe the synthetic strategies to gold(I)-selenolate complexes by the reaction of ortho-substituted diaryl diselenides and electrophilic anti-arthritic gold(I)-compounds in the presence of thiol such as PhSH. Diselenides react with thiol to generate a mixture of selenol and selenenyl sulfide. While selenols react with electrophilic Au(I) compounds to form gold(I)-selenolate complexes, the selenenyl sulfides do not react and therefore, a prior conversion of selenenyl su...
#1Taotao Zou (HKU: University of Hong Kong)H-Index: 18
#2Ching Tung Lum (HKU: University of Hong Kong)H-Index: 14
Last. ChiMingCHE (HKU: University of Hong Kong)H-Index: 104
view all 5 authors...
Gold complexes have recently gained increasing attention in the design of new metal-based anticancer therapeutics. Gold(III) complexes are generally reactive/unstable under physiological conditions via intracellular redox reactions, and the intracellular AuIII to AuI reduction reaction has recently been “traced” by the introduction of appropriate fluorescent ligands. Similar to most Au(I) complexes, Au(III) complexes can inhibit the activities of thiol-containing enzymes, including thioredoxin r...
184 CitationsSource
#1Peter A. Ajibade (University of Fort Hare)H-Index: 19
#2Nonkululeko H. Zulu (University of Fort Hare)H-Index: 3
Last. Adebola O. Oyedeji (Walter Sisulu University)H-Index: 9
view all 3 authors...
Co(II), Cu(II), and Zn(II) complexes of diethylthiourea and dimethylthiourea have been synthesized and characterized by elemental analysis, conductivity, magnetic susceptibility measurements, and FTIR UV-vis spectroscopy. The single-crystal X-ray structure of the Co(II) complex of diethylthiourea, [CoCl2(detu)2], is reported. The metal(II) complexes are four coordinated with two molecules of the alkyl thiourea and two molecules of either chloride or acetate ions. The compounds are nonelectrolyte...
6 CitationsSource
#1Krishna P. Bhabak (IISc: Indian Institute of Science)H-Index: 16
#2Bhaskar J. Bhuyan (IISc: Indian Institute of Science)H-Index: 6
Last. Govindasamy Mugesh (IISc: Indian Institute of Science)H-Index: 38
view all 3 authors...
Gold(I)-based drugs have been used successfully for the treatment of rheumatoid arthritis (RA) for several years. Although the exact mechanism of action of these gold(I) drugs for RA has not been clearly established, the interaction of these compounds with mammalian enzymes has been extensively studied. In this paper, we describe the interaction of therapeutic gold(I) compounds with mammalian proteins that contain cysteine (Cys) and selenocysteine (Sec) residues. Owing to the higher affinity of ...
65 CitationsSource
#1Eduardo J. Fernándeza (UR: University of La Rioja)H-Index: 1
#2Emma García-Luzuriagaa (UR: University of La Rioja)H-Index: 1
Last. M. Elena Olmosa (UR: University of La Rioja)H-Index: 1
view all 5 authors...
containing the S,N-donor ligand 2-(diphenylthiop hosphino)aniline (S=PNH 2 ) can be easily prepared by treatment of S=PNH 2 with [Au(C 6 F 5 ) 2 (OEt 2 ) 2 ]ClO 4 and deprotonated with PPN(acac) to afford [Au(C 6 F 5 ) 2 (SPNH)] (2). Complex 2 can also be obtained in a one-step reaction from SPNH 2 and [Au(C 6 F 5 ) 2 (acac)]. The electronic density in excess in 2 can be employed to incorporate a new metallic fragment to give the mixed complexes [Au(C 6 F 5 ) 2 {SPNH(MPPh 3 )}]ClO 4 (M = Au (3),...
1 CitationsSource