OR39

Pre-transplant (txp) sensitization in patients awaiting heart transplants put them at an increased risk post-txp of mortality, rejection, and chronic allograft vasculopathy and also reduces the pool of available donors. Many of the deleterious effects of the HLA antibodies (abs) are associated with their ability to activate the complement cascade. Recent reports have highlighted the correlation between C1q-binding donor-specific HLA abs (DSA)...