Synergistic anti-tumor efficacy of doxorubicin and flavopiridol in an in vivo hepatocellular carcinoma model.

Published on Nov 1, 2015in Journal of Cancer Research and Clinical Oncology3.332
· DOI :10.1007/s00432-015-1990-6
Min Sun Kwak13
Estimated H-index: 13
(SNU: Seoul National University),
Su Jong Yu22
Estimated H-index: 22
(SNU: Seoul National University)
+ 6 AuthorsChung Yong Kim31
Estimated H-index: 31
(SNU: Seoul National University)
Purpose A previous study showed that flavopiridol increased doxorubicin sensitivity in hypoxic hepatocellular carcinoma (HCC) cells by increasing apoptosis through suppressing hypoxia-inducible N-myc downstream-regulated gene-1 (NDRG1) expression. However, this has not been investigated in an in vivo HCC model. Therefore, we aimed to elucidate whether the combination of doxorubicin and flavopiridol has a synergistic anti-tumor effect in an in vivo HCC model.
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