Review paper
Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease
Abstract
Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic infection in the general population. Emerging evidence that PML can be ameliorated with novel immunotherapeutic approaches calls for reassessment of PML pathophysiology and clinical course. PML results from JCV reactivation in the setting of impaired cellular immunity, and no...
Figures & Tables
Fig. 2 | Pathophysiology of PML. According to the three- stage model of progress...
Table 1 | Summary of diagnostic criteria for PML
Paper Details
Title
Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease
Published Date
Nov 20, 2020
Journal
Volume
17
Issue
1
Pages
37 - 51
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