Prostate cancer reactivates developmental epigenomic programs during metastatic progression

Volume: 52, Issue: 8, Pages: 790 - 799
Published: Jul 20, 2020
Abstract
Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the dependency of PCa cells on the androgen receptor (AR), a prostate master transcription factor. We generated 268 epigenomic datasets spanning two state transitions—from normal prostate epithelium to localized PCa to metastases—in specimens derived from human tissue. We discovered that reprogrammed AR sites in metastatic PCa are not created de novo; rather, they are...
Paper Details
Title
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
Published Date
Jul 20, 2020
Volume
52
Issue
8
Pages
790 - 799
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