Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination
Abstract
Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as Charcot-Marie-Tooth disease in humans. During Schwann cell development and myelination chromatin is dramatically modified. However, impact and functional relevance of these modifications are poorly understood. Here, we analyzed histone H2B monoubiquitination...
Paper Details
Title
Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination
Published Date
Jul 16, 2020
Journal
Volume
48
Issue
16
Pages
8959 - 8976
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