Impact of high tumor mutational burden in solid tumors and challenges for biomarker application
Abstract
Accurate identification of patients with solid tumors likely to respond to immunotherapy is crucial. Tumor mutational burden (TMB) measures the number of somatic mutations in a tumor and is an emerging prognostic and predictive biomarker for anti-programmed cell death (PD) 1/anti-PD-ligand 1 therapy and other immunotherapeutic agents. Tumor mutational burden is assessed optimally by whole exome sequencing, but next generation sequencing provides...
Paper Details
Title
Impact of high tumor mutational burden in solid tumors and challenges for biomarker application
Published Date
Sep 1, 2020
Journal
Volume
89
Pages
102084 - 102084
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