Functions of the plasminogen receptor Plg‐RKT

Plg‐RKT is a structurally unique transmembrane plasminogen receptor with both N‐ and C‐terminal domains exposed on the extracellular face of the cell. Its C‐terminal lysine functions to tether plasminogen to cell surfaces. Overexpression of Plg‐RKT increases cell surface plasminogen binding capacity while genetic deletion of Plg‐RKT decreases plasminogen binding. Plasminogen binding to Plg‐RKT results in promotion of plasminogen activation to...