Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery
Abstract
Circadian clocks are endogenous oscillators that control ∼24-hour physiology and behaviors in virtually all organisms. The circadian oscillator comprises interconnected transcriptional and translational feedback loops, but also requires finely coordinated protein homeostasis including protein degradation and maturation. However, the mechanisms underlying the mammalian clock protein maturation is largely unknown. In this study, we demonstrate...
Paper Details
Title
Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery
Published Date
Jul 15, 2020
Journal
Volume
48
Issue
14
Pages
7944 - 7957
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