CRISPR-CasΦ from huge phages is a hypercompact genome editor
Abstract
Compact defense system in bacteriophages The CRISPR-Cas system, naturally found in many prokaryotes, is widely used for genome editing. CRISPR arrays in the bacterial genome, derived from the genome of invading viruses, are used to generate a CRISPR RNA that guides the Cas enzyme to destroy repeat viral invaders. Recently, an unexpectedly compact CRISPR-Cas system was identified in huge bacteriophages. Pausch et al . show that even though this...
Paper Details
Title
CRISPR-CasΦ from huge phages is a hypercompact genome editor
Published Date
Jul 17, 2020
Journal
Volume
369
Issue
6501
Pages
333 - 337
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