Original paper

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Issue: 161
Published: Jul 17, 2020
Abstract
The Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by the PTPN11 proto-oncogene, is a key mediator of receptor tyrosine kinase (RTK)-driven cell signaling, promoting cell survival and proliferation. In addition, SHP2 is recruited by immune check point receptors to inhibit B and T cell activation. Aberrant SHP2 function has been implicated in the development, progression, and metastasis of many cancers. Indeed, small...
Paper Details
Title
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
Published Date
Jul 17, 2020
Issue
161
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