Skeletal Muscle Endurance And Oxygen Uptake Kinetics During Cycling In Patients With High Affinity Hemoglobin

Skeletal muscle oxygen (O2) consumption is linked to the metabolic demand of the exercising skeletal muscle. In hypoxic conditions (e.g. high altitude) O2 consumption may be the limiting factor of exercise tolerance. Patients with increased O2 content, secondary to an increased oxygen affinity (HAH), provide an experiment of nature to investigate the effects of increased flux through the O2 transport pathway on exercise tolerance. PURPOSE: To...