The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders

Volume: 19, Issue: 8
Published: Jul 1, 2020
Abstract
Paternal aging and the prevalence of neurodevelopmental disorders in offspring are well documented. Yet, the underlying mechanism and the mode of inheritance have not been conclusively established. Advancing paternal age is a subtle and varying phenotype. As such, it is likely that a threshold for cumulative risk may exist that, if surpassed, culminates in a predisposition to disease and ultimately an observed phenotype in offspring. Epigenetic...
Paper Details
Title
The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders
Published Date
Jul 1, 2020
Journal
Volume
19
Issue
8
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