Highly efficient generation of sheep with a defined FecBB mutation via adenine base editing
Abstract
Base editing has the potential to improve important economic traits in agriculture and can precisely convert single nucleotides in DNA or RNA sequences into minimal double-strand DNA breaks (DSB). Adenine base editors (ABE) have recently emerged as a base editing tool for the conversion of targeted A:T to G:C, but have not yet been used in sheep. ABEmax is one of the latest versions of ABE, which consists of a catalytically-impaired nuclease and...
Paper Details
Title
Highly efficient generation of sheep with a defined FecBB mutation via adenine base editing
Published Date
Jul 1, 2020
Journal
Volume
52
Issue
1
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