Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination
Abstract
null Immunoglobulin heavy chain locus (Igh) VH, D, and JH gene segments are developmentally assembled into V(D)J exons. RAG endonuclease initiates V(D)J recombination by binding a JH-recombination signal sequence (RSS) within a chromatin-based recombination center (RC) and then, in an orientation-dependent process, scans upstream D-containing chromatin presented by cohesin-mediated loop extrusion for convergent D-RSSs to initiate DJH-RC...
Paper Details
Title
Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination
Published Date
Jul 2, 2020
Journal
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