Oral squamous cell carcinoma diagnosed from saliva metabolic profiling

Significance We show that the combination of conductive polymer spray mass spectrometry (CPSI-MS) and machine learning provides a simple, fast, and affordable method for oral squamous cell carcinoma diagnosis with 86.7% accuracy. By using CPSI-MS, the direct, high-throughput metabolic profiling of saliva can be readily realized in a noninvasive manner. The self-conductive materials used in CPSI-MS for sample loading and ionization are clean,...